用于难溶性药物的水凝胶基药物递送系统

McKenzie Matthew, Betts David, Suh Amy, Bui Kathryn, Kim London Doyoung, Cho Hyunah

Pharmaceutical and Administrative Sciences, St. Louis College of Pharmacy, 4588 Parkview Place, St. Louis, MO 63110, USA.

Molecules. 2015 Nov 13;20(11):20397-408. doi: 10.3390/molecules201119705.

Hydrogels are three-dimensional materials that can withstand a great amount of water incorporation while maintaining integrity. This allows hydrogels to be very unique biomedical materials, especially for drug delivery. Much effort has been made to incorporate hydrophilic molecules in hydrogels in the field of drug delivery, while loading of hydrophobic drugs has not been vastly studied. However, in recent years, research has also been conducted on incorporating hydrophobic molecules within hydrogel matrices for achieving a steady release of drugs to treat various ailments. Here, we summarize the types of hydrogels used as drug delivery vehicles, various methods to incorporate hydrophobic molecules in hydrogel matrices, and the potential therapeutic applications of hydrogels in cancer.

水凝胶是三维材料，能够吸收大量水分并保持完整性。这使得水凝胶成为非常独特的生物医学材料，尤其适用于药物递送。在药物递送领域，人们已经付出了很多努力将亲水分子纳入水凝胶中，而疏水性药物的负载尚未得到广泛研究。然而，近年来，也开展了关于将疏水分子纳入水凝胶基质以实现药物稳定释放来治疗各种疾病的研究。在此，我们总结了用作药物递送载体的水凝胶类型、将疏水分子纳入水凝胶基质的各种方法，以及水凝胶在癌症治疗中的潜在应用。