Westrin A
Department of Clinical Neuroscience, Lund University, Sweden.
Biomed Pharmacother. 2000 Apr;54(3):142-5. doi: 10.1016/S0753-3322(00)89047-2.
Stress system alterations, in particular HPA axis hyperactivations, are fairly well documented in suicide victims and in depressed suicide attempters who subsequently complete suicide. In suicide attempters with no documented completed suicide, the results are more inconsistent. This may depend on differences in studies due to diagnostic heterogeneity among suicide attempters, and the time between the suicide attempt and the examination. Recent data suggests differences in the stress system between depressed patients with a recent suicide attempt and depressed patients in general. The field merits further examination, with thorough examinations of genotypes, actual suicide attempts and stress in combination with examinations of the stress system.
应激系统改变，尤其是下丘脑-垂体-肾上腺（HPA）轴的过度激活，在自杀受害者以及随后完成自杀的抑郁自杀未遂者中已有相当充分的记录。在没有记录显示已完成自杀的自杀未遂者中，结果则更为不一致。这可能取决于研究中的差异，原因在于自杀未遂者之间存在诊断异质性，以及自杀未遂与检查之间的时间间隔。最近的数据表明，近期有自杀未遂的抑郁症患者与一般抑郁症患者的应激系统存在差异。该领域值得进一步研究，要对基因型、实际自杀未遂情况和应激进行全面检查，并结合对应激系统的检查。
