Programa de Pós-Graduação em Saúde & Comportamento, Centro de Ciências da Vida e da Saúde, Universidade Católica de Pelotas, Rua Gonçalves Chaves, 373 sala 411C, Pelotas, RS CEP 96015-560, Brazil.
Neurochem Res. 2012 Oct;37(10):2229-34. doi: 10.1007/s11064-012-0851-9. Epub 2012 Aug 1.
Our aim was to investigate serum brain-derived neurotrophic factor (BDNF) levels in postpartum women, according to the presence of postpartum affective disorder (PPAD) and suicidality. A cross-sectional study was carried out with women between 45 and 90 days after delivery. PPAD (depression, manic and mixed episode) and suicide risk were assessed using the Mini International Neuropsychiatric Interview. BDNF was assessed using a commercial ELISA kit. Linear regression was used for multivariate analyses. A hundred ninety women participated in the study, 15.3 % had PPAD, 7.4 % showed PPAD with suicide risk. BDNF levels were lower in subjects with three or more Stressful Life Events (P = 0.01). The serum BDNF levels of women with PPAD presenting suicide risk were significantly lower than those of women without suicide risk (1.50 ± 1.38 and 2.33 ± 1.28 ng/ml, P = 0.02). Clinicians should enquire postpartum women about their history of stressful life events, PPAD, and suicidality. This study shows the potential role of BDNF in the neurobiology of the association of PPAD and suicidality.
我们的目的是根据产后情绪障碍（PPAD）和自杀风险的存在，调查产后妇女的血清脑源性神经营养因子（BDNF）水平。对产后 45 至 90 天的妇女进行了横断面研究。使用 Mini 国际神经精神访谈评估 PPAD（抑郁、躁狂和混合发作）和自杀风险。使用商业 ELISA 试剂盒评估 BDNF。采用线性回归进行多变量分析。190 名妇女参加了研究，15.3%有 PPAD，7.4%有自杀风险的 PPAD。经历 3 次或以上生活压力事件的受试者的 BDNF 水平较低（P = 0.01）。有自杀风险的 PPAD 妇女的血清 BDNF 水平明显低于无自杀风险的妇女（1.50 ± 1.38 和 2.33 ± 1.28ng/ml，P = 0.02）。临床医生应询问产后妇女的生活压力事件、PPAD 和自杀史。本研究表明 BDNF 在 PPAD 和自杀风险相关的神经生物学中具有潜在作用。
