α-1-抗胰蛋白酶，一种肾素抑制剂。
alpha-1-Anti-trypsin, an inhibitor of renin.
作者信息
Scharpé S, Eid M, Cooreman W, Lauwers A
出版信息
Biochem J. 1976 Feb 1;153(2):505-7. doi: 10.1042/bj1530505.
Abstract
A naturally occurring competitive inhibitor of pig kidney renin has been identified in human plasma. The inhibitor was shown to be alpha-1 anti-trypsin and the effect in vitro on the renin activity was examined. The slope in the Hill plot is compatible with the assumption of one-site competitive inhibition. Other proteinase inhibitors, such as alpha-2-macroglobulin and C1 inactivator, however, have no inhibitory effect on the renin-angiotensinogen reaction.
摘要
在人血浆中已鉴定出一种天然存在的猪肾肾素竞争性抑制剂。该抑制剂被证明是α-1抗胰蛋白酶，并对其体外对肾素活性的影响进行了研究。希尔图中的斜率与单位点竞争性抑制的假设相符。然而，其他蛋白酶抑制剂，如α-2-巨球蛋白和C1灭活剂，对肾素-血管紧张素原反应没有抑制作用。
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The determination of enzyme inhibitor constants.酶抑制剂常数的测定
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Biochemical and physicochemical studies on renin.肾素的生物化学与物理化学研究。
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A naturally occurring renin inhibitor.一种天然存在的肾素抑制剂。
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Plasma phospholipase A2 activity in nephrectomized rats and the question of renin inhibition.肾切除大鼠的血浆磷脂酶A2活性及肾素抑制问题。
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Renin: inhibition by proteins and peptides.肾素：受蛋白质和肽类的抑制作用。
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Isolation and properties of human plasma alpha-1-proteinase inhibitor.人血浆α-1-蛋白酶抑制剂的分离与特性
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Application of a radioimmunoassay for angiotensin I to the physiologic measurements of plasma renin activity in normal human subjects.一种用于血管紧张素I的放射免疫测定法在正常人体血浆肾素活性生理测量中的应用。
J Clin Endocrinol Metab. 1969 Oct;29(10):1349-55. doi: 10.1210/jcem-29-10-1349.
10
Molecular order of participation of inhibitors (or activators) in biological systems.抑制剂（或激活剂）参与生物系统的分子顺序。
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