Remigio P A, Der B K, Forsberg R T
Dis Colon Rectum. 1976 May-Jun;19(4):350-6. doi: 10.1007/BF02590934.
We have described the clinicopathologic findings in two cases of anorectal melanoma, and extracted the salient features from the medical literature. The disease is rare. Melanoma arises from the anal squamous membrane and very often spreads upward through submucosal planes, producing secondary satelites in the rectum. Trauma from defecation, vast lymphatic and venous systems in the anorectal region, and high invasiveness of the tumor cells eviden;ly account for early distant metastases. Histologically, the neoplastic cells often mimic other cancers. Treatment is surgical, with dismal end results.
我们描述了两例肛管直肠黑色素瘤的临床病理表现，并从医学文献中提取了显著特征。这种疾病很罕见。黑色素瘤起源于肛管鳞状膜，常常通过黏膜下层平面向上扩散，在直肠产生继发性卫星灶。排便造成的创伤、肛管直肠区域庞大的淋巴和静脉系统以及肿瘤细胞的高侵袭性显然是早期远处转移的原因。在组织学上，肿瘤细胞常常类似于其他癌症。治疗方法是手术，但最终结果不佳。
