Miyahara M, Saito T, Sato K, Kaketani K, Yoshida T, Inomata M, Kobayashi M, Yoshikawa K
First Department of Surgery, Medical College, Oita, Japan.
Surg Today. 1992;22(2):171-5. doi: 10.1007/BF00311345.
A case of primary anorectal malignant melanoma seen in a 46 year old woman is presented herein. Her most marked symptoms were bloody stools and anal pain. Endoscopic examination indicated a tumor with ulceration but without pigmentation in the anorectal region. Histologic examination of the biopsied specimens showed spindle-shaped cells with atypia proliferating in a bandlike arrangement, as in leiomyosarcoma. An abdominoperineal resection was done and detailed histological examination of the tumor confirmed the nature of the tumor to be malignant melanoma. The postoperative immunochemotherapy consisted of Dimetyl-Triazeno-Imidasole-Carboxamide (DTIC), Amino-Methyl-Pyrimidinyl-Methyl-Chlorethyl-Nitrosourea-Hydrochlori de (ACNU), Vincristine (VCR) and OK-432. The patient has been well without recurrence for fifteen months following her operation through the continuous administration of these agents.
本文介绍了一名46岁女性原发性肛门直肠恶性黑色素瘤病例。她最明显的症状是便血和肛门疼痛。内镜检查显示肛门直肠区域有一个伴有溃疡但无色素沉着的肿瘤。活检标本的组织学检查显示梭形细胞伴异型性，呈束状排列增生，类似平滑肌肉瘤。进行了腹会阴切除术，对肿瘤的详细组织学检查证实肿瘤性质为恶性黑色素瘤。术后免疫化疗包括氮烯咪胺（DTIC）、嘧啶亚硝脲（ACNU）、长春新碱（VCR）和溶链菌制剂（OK-432）。通过持续使用这些药物，患者术后15个月情况良好，无复发。
