处于平衡状态的（CKB×CWB）F1四亲代小鼠C3H对聚-L（酪氨酸，谷氨酸）-聚-D，L-丙氨酸-聚-L-赖氨酸免疫的抗体反应。
Antibody response of C3H in equilibrium (CKB X CWB)F1 tetraparental mice to poly-L(Tyr,Glu)-poly-D,L-Ala-poly-L-Lys immunization.
作者信息
Bechtol K B, McDevitt H O
出版信息
J Exp Med. 1976 Jul 1;144(1):123-44. doi: 10.1084/jem.144.1.123.
Abstract
To test whether the antigen-specific stimulation of low responder-genotype B cells in tetraparental mice is due to a histoincompatibility reaction (allogeneic effect) against these B cells, tetraparental mice were constructed (a) between an Ir-1A low responder to the antigen poly-L(Tyr,Glu)-poly-D,L-Ala--poly-L-Lys. [(T,G)-A--L] and an Ir-1A F1 high responder and (b) between two histoincompatible Ir-lA low responders. In the first case the F1 high responder embryo shares the whole of the H-2 complex, including Ir, with the low responder embryo.
摘要
为了检验四亲代小鼠中低反应基因型B细胞的抗原特异性刺激是否归因于针对这些B细胞的组织不相容性反应（同种异体效应），构建了四亲代小鼠：(a) 在对抗原聚-L(酪氨酸,谷氨酸)-聚-D,L-丙氨酸-聚-L-赖氨酸[（T,G）-A-L]呈Ir-1A低反应性的小鼠与Ir-1A F1高反应性小鼠之间；(b) 在两个组织不相容的Ir-1A低反应性小鼠之间。在第一种情况下，F1高反应性胚胎与低反应性胚胎共享整个H-2复合体，包括Ir基因座。
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Antibody response of C3H in equilibrium (CKB X CWB)F1 tetraparental mice to poly-L(Tyr,Glu)-poly-D,L-Ala-poly-L-Lys immunization.处于平衡状态的（CKB×CWB）F1四亲代小鼠C3H对聚-L（酪氨酸，谷氨酸）-聚-D，L-丙氨酸-聚-L-赖氨酸免疫的抗体反应。
J Exp Med. 1976 Jul 1;144(1):123-44. doi: 10.1084/jem.144.1.123.
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本文引用的文献
1
Studies on artifical antigens. I. Antigenicity of DNP-polylysine and DNP copolymer of lysine and glutamic acid in guinea pigs.人工抗原的研究。I. 二硝基苯-聚赖氨酸及赖氨酸与谷氨酸的二硝基苯共聚物在豚鼠体内的抗原性
J Exp Med. 1963 Jan 1;117(1):55-69. doi: 10.1084/jem.117.1.55.
2
Studies on the chemical basis of the antigenicity of proteins. 5. Synthesis, characterization and immunogenicity of some multichain and linear polypeptides containing tyrosine.蛋白质抗原性的化学基础研究。5. 一些含酪氨酸的多链和线性多肽的合成、表征及免疫原性
Biochem J. 1962 Oct;85(1):223-35. doi: 10.1042/bj0850223.
3
Congenic mouse strains with different immunoglobulin allotypes. I. Breeding scheme, histocompatibility tests, and kinetics of gamma G2a-globulin production by transferred cells for C3H.SW and its congenic partner CWB/5.具有不同免疫球蛋白同种异型的同类系小鼠品系。I. C3H.SW及其同类系伙伴CWB/5的繁殖方案、组织相容性测试以及转移细胞产生γG2a球蛋白的动力学。
Transplantation. 1967 Nov;5(6):1484-95. doi: 10.1097/00007890-196711000-00013.
4
The behavior of hapten-poly-L-lysine conjugates as complete antigens in genetic responder and as haptens in nonresponder guinea pigs.半抗原-聚-L-赖氨酸缀合物在遗传应答豚鼠中作为完全抗原的行为以及在无应答豚鼠中作为半抗原的行为。
J Exp Med. 1966 May 1;123(5):859-79. doi: 10.1084/jem.123.5.859.
5
Genetic control of the antibody response. I. Demonstration of determinant-specific differences in response to synthetic polypeptide antigens in two strains of inbred mice.抗体反应的遗传控制。I. 两个近交系小鼠对合成多肽抗原反应中决定簇特异性差异的证明。
J Exp Med. 1965 Sep 1;122(3):517-31. doi: 10.1084/jem.122.3.517.
6
Gene control of hematopoiesis. I. Erythrocyte mosaicism and permanent immunological tolerance in allophenic mice.造血作用的基因控制。I. 异表型小鼠中的红细胞嵌合体和永久免疫耐受性。
J Exp Med. 1969 May 1;129(5):1013-27. doi: 10.1084/jem.129.5.1013.
7
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Science. 1969 Mar 14;163(3872):1207-8. doi: 10.1126/science.163.3872.1207.
8
9
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J Exp Med. 1971 Nov 1;134(5):1335-48. doi: 10.1084/jem.134.5.1335.
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