体外抗体应答的细胞与遗传控制。II. 对聚-L-（酪氨酸，谷氨酸）-聚-D，L-丙氨酸-聚-L-赖氨酸及聚-L-（组氨酸，谷氨酸）-聚-D，L-丙氨酸-聚-L-赖氨酸的三硝基苯基缀合物的初次IgM应答的Ir基因控制
Cellular and genetic control of antibody responses in vitro. II. Ir gene control of primary IgM responses to trinitrophenyl conjugates of poly-L-(Tyr,Glu)-poly-D,L-Ala--poly-L-Lys and poly-L-(His,Glu)-poly-D,L-Ala--poly-L-Lys.
作者信息
Singer A, Dickler H B, Hodes R J
出版信息
J Exp Med. 1977 Oct 1;146(4):1096-107. doi: 10.1084/jem.146.4.1096.
Abstract
The in vitro primary IgM anti-hapten responses to trinitrophenyl (TNP) conjugates of poly-L-(Tyr,Glu)-poly-D,L-Ala-poly-L-Lys (T,G)-A--L and poly-L(His,Glu)-poly-D,L-Ala--poly-L-Lys (H,G)-A--L were shown to be T-cell dependent and under autosomal dominant H-2-linked Ir gene control which mapped within the K or I-A regions of the H-2 complex. The in vitro response to TNP-keyhole limpet hemocyanin, while T-dependent, was not under demonstrable genetic control. The genes governing the in vitro primary IgM anti-hapten responses to TNP-(T,G)-A--L and TNP-(H,G)-A--L resemble the Ir genes controlling the in vivo secondary IgG responses to (T,G)-A--L and (H,G)-A--L in that they are autosomal dominant, map identically within the H-2 complex, and have identical responder and nonresponder haplotypes. It is concluded that Ir genes can govern the ability to generate an IgM response upon initial exposure to antigen.
摘要
研究表明，针对聚-L-(酪氨酸,谷氨酸)-聚-D,L-丙氨酸-聚-L-赖氨酸（T,G）-A--L和聚-L(组氨酸,谷氨酸)-聚-D,L-丙氨酸-聚-L-赖氨酸（H,G）-A--L的三硝基苯基（TNP）偶联物的体外原发性IgM抗半抗原反应是T细胞依赖性的，并受常染色体显性H-2连锁Ir基因控制，该基因定位于H-2复合体的K或I-A区域内。对TNP-匙孔血蓝蛋白的体外反应虽然是T细胞依赖性的，但不受明显的基因控制。控制对TNP-(T,G)-A--L和TNP-(H,G)-A--L的体外原发性IgM抗半抗原反应的基因类似于控制对(T,G)-A--L和(H,G)-A--L的体内继发性IgG反应的Ir基因，因为它们是常染色体显性的，在H-2复合体内定位相同，并且具有相同的反应者和无反应者单倍型。得出的结论是，Ir基因可以控制初次接触抗原时产生IgM反应的能力。
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Cellular and genetic control of antibody responses in vitro. II. Ir gene control of primary IgM responses to trinitrophenyl conjugates of poly-L-(Tyr,Glu)-poly-D,L-Ala--poly-L-Lys and poly-L-(His,Glu)-poly-D,L-Ala--poly-L-Lys.体外抗体应答的细胞与遗传控制。II. 对聚-L-（酪氨酸，谷氨酸）-聚-D，L-丙氨酸-聚-L-赖氨酸及聚-L-（组氨酸，谷氨酸）-聚-D，L-丙氨酸-聚-L-赖氨酸的三硝基苯基缀合物的初次IgM应答的Ir基因控制
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引用本文的文献
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The free amino groups of insulin.胰岛素的游离氨基
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Genetic control of the immune response. Mapping of the Ir-1 locus.免疫反应的遗传控制。Ir-1基因座的定位。
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Genetic control of the immune response. The effect of thymectomy on the primary and secondary antibody response of mice to poly-L(tyr, glu)-poly-D, L-ala--poly-L-lys.免疫反应的遗传控制。胸腺切除对小鼠针对聚-L（酪氨酰、谷氨酰）-聚-D，L-丙氨酰-聚-L-赖氨酸的初次和二次抗体反应的影响。
J Exp Med. 1972 Jan;135(1):126-35. doi: 10.1084/jem.135.1.126.
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Genetic control of the immune response. A selective defect in immunologic (IgG) memory in nonresponder mice.免疫反应的遗传控制。无反应小鼠免疫（IgG）记忆中的选择性缺陷。
J Exp Med. 1972 Jan;135(1):110-25. doi: 10.1084/jem.135.1.110.
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Antigen-specific thymus cell factors in the genetic control of the immune response to poly-(tyrosyl, glutamyl)-poly-D, L-alanyl--poly-lysyl.抗原特异性胸腺细胞因子在对聚（酪氨酰、谷氨酰）-聚-D，L-丙氨酰-聚赖氨酸免疫应答的遗传控制中。
J Exp Med. 1974 Aug 1;140(2):301-12. doi: 10.1084/jem.140.2.301.
10
Genetic control of immune responses in vitro. I. Development of primary and secondary plaque-forming cell responses to the random terpolymer 1-glutamic acid 60-1-alanine30-1-tyrosine10 (GAT) by mouse spleen cells in vitro.体外免疫反应的遗传控制。I. 小鼠脾细胞在体外对随机三元共聚物1-谷氨酸60-1-丙氨酸30-1-酪氨酸10（GAT）的初次和二次噬斑形成细胞反应的发展。
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