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1
Studies on artifical antigens. I. Antigenicity of DNP-polylysine and DNP copolymer of lysine and glutamic acid in guinea pigs.人工抗原的研究。I. 二硝基苯-聚赖氨酸及赖氨酸与谷氨酸的二硝基苯共聚物在豚鼠体内的抗原性
J Exp Med. 1963 Jan 1;117(1):55-69. doi: 10.1084/jem.117.1.55.
2
Polyfunctional dinitrophenyl haptens as reagents for elicitation of immediate type allergic skin responses.作为引发速发型过敏性皮肤反应试剂的多功能二硝基苯基半抗原
J Exp Med. 1962 Apr 1;115(4):789-801. doi: 10.1084/jem.115.4.789.
3
Transfer of responsiveness to hapten conjugates of poly-L-lysine and of a copolymer of L-glutamic acid and L-lysine to lethally irradiated nonresponder guinea pigs by bone marrow or lymph node and spleen cells from responder guinea pigs.通过来自有反应性豚鼠的骨髓或淋巴结及脾细胞，将对多聚-L-赖氨酸以及L-谷氨酸与L-赖氨酸共聚物的半抗原共轭物的反应性转移给经致死剂量照射的无反应性豚鼠。
J Exp Med. 1969 Nov 1;130(5):1107-22. doi: 10.1084/jem.130.5.1107.
4
STUDIES ON ANTIGENICITY. THE RELATIONSHIP BETWEEN IN VIVO AND IN VITRO ENZYMATIC DEGRADABILITY OF HAPTEN-POLYLYSINE CONJUGATES AND THEIR ANTIGENICITIES IN GUINEA PIGS.抗原性研究。豚鼠体内外半抗原-多聚赖氨酸缀合物的酶促降解性与其抗原性之间的关系。
J Exp Med. 1964 Nov 1;120(5):955-65. doi: 10.1084/jem.120.5.955.
5
The behavior of hapten-poly-L-lysine conjugates as complete antigens in genetic responder and as haptens in nonresponder guinea pigs.半抗原-聚-L-赖氨酸缀合物在遗传应答豚鼠中作为完全抗原的行为以及在无应答豚鼠中作为半抗原的行为。
J Exp Med. 1966 May 1;123(5):859-79. doi: 10.1084/jem.123.5.859.
6
STUDIES ON ARTIFICIAL ANTIGENS. III. THE GENETIC CONTROL OF THE IMMUNE RESPONSE TO HAPTEN-POLY-L-LYSINE CONJUGATES IN GUINEA PIGS.人工抗原的研究。III. 豚鼠对半抗原-聚-L-赖氨酸缀合物免疫反应的遗传控制。
J Exp Med. 1963 Dec 1;118(6):953-7. doi: 10.1084/jem.118.6.953.
7
Chemically related antigens compete for presentation by accessory cells to T cells.化学相关抗原竞争由辅助细胞呈递给T细胞。
J Immunol. 1982 Nov;129(5):1883-91.
8
Genetic control of immunological responsiveness in guinea pigs to 2,4-dinitrophenyl conjugates of poly-L-arginine, protamine, and poly-L-ornithine.豚鼠对聚-L-精氨酸、鱼精蛋白和聚-L-鸟氨酸的2,4-二硝基苯基缀合物免疫反应性的遗传控制。
Proc Natl Acad Sci U S A. 1969 Nov;64(3):1095-102. doi: 10.1073/pnas.64.3.1095.
9
Antigen recognition and antibody specificity. Carrier specificity and genetic control of anti-dinitrophenyl-oligolysine antibody.抗原识别与抗体特异性。抗二硝基苯基-寡聚赖氨酸抗体的载体特异性与遗传控制。
J Exp Med. 1971 Jun 1;133(6):1199-218. doi: 10.1084/jem.133.6.1199.
10
Specificity and genetic restrictions of the guinea-pig immune response to dinitrophenyl-lysyl-alanyl octapeptides.豚鼠对二硝基苯基 - 赖氨酰 - 丙氨酰八肽免疫反应的特异性和遗传限制
Immunology. 1978 Nov;35(5):763-9.

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1
Toward a Network Model of MHC Class II-Restricted Antigen Processing.迈向MHC II类限制性抗原加工的网络模型。
Front Immunol. 2013 Dec 16;4:464. doi: 10.3389/fimmu.2013.00464.
2
Toward a molecular understanding of adaptive immunity: a chronology, part I.朝着对适应性免疫的分子理解迈进：一个年表，第一部分。
Front Immunol. 2012 Dec 6;3:369. doi: 10.3389/fimmu.2012.00369. eCollection 2012.
3
STUDIES ON DELAYED HYPERSENSITIVITY. I. INFERENCES ON THE COMPARATIVE BINDING AFFINITIES OF ANTIBODIES MEDIATING DELAYED AND IMMEDIATE HYPERSENSITIVITY REACTIONS IN THE GUINEA PIG.迟发型超敏反应研究。I. 关于介导豚鼠迟发型和速发型超敏反应的抗体相对结合亲和力的推论
J Exp Med. 1965 Jun 1;121(6):873-88. doi: 10.1084/jem.121.6.873.
4
STUDIES ON ANTIGENICITY. THE RELATIONSHIP BETWEEN IN VIVO AND IN VITRO ENZYMATIC DEGRADABILITY OF HAPTEN-POLYLYSINE CONJUGATES AND THEIR ANTIGENICITIES IN GUINEA PIGS.抗原性研究。豚鼠体内外半抗原-多聚赖氨酸缀合物的酶促降解性与其抗原性之间的关系。
J Exp Med. 1964 Nov 1;120(5):955-65. doi: 10.1084/jem.120.5.955.
5
IN VITRO STUDIES OF CELLULAR HYPERSENSITIVITY. II. RELATIONSHIP OF DELAYED HYPERSENSITIVITY AND INHIBITION OF CELL MIGRATION BY PICRYLATED PROTEINS.细胞超敏反应的体外研究。II. 迟发型超敏反应与苦味酸蛋白对细胞迁移抑制作用的关系。
J Exp Med. 1964 Dec 1;120(6):1231-43. doi: 10.1084/jem.120.6.1231.
6
THEORIES OF ANTIBODY FORMATION: A REVIEW.抗体形成理论综述
Yale J Biol Med. 1964 Aug;37(1):1-30.
7
ANTIGENICITY OF POLYPEPTIDES (POLY ALPHA AMINO ACIDS). XII. IMMUNOLOGICAL STUDIES WITH A NEW GROUP OF SYNTHETIC COPOLYMERS.多肽（聚α-氨基酸）的抗原性。十二。一组新型合成共聚物的免疫学研究。
J Exp Med. 1964 Jan 1;119(6):1005-15. doi: 10.1084/jem.119.6.1005.
8
DIFFERENCES IN THE ELECTROPHORETIC MOBILITIES OF GUINEA PIG 7S ANTIBODIES OF DIFFERENT SPECIFICITIES.不同特异性豚鼠7S抗体的电泳迁移率差异
J Exp Med. 1964 Mar 1;119(3):409-23. doi: 10.1084/jem.119.3.409.
9
STUDIES ON ARTIFICIAL ANTIGENS. III. THE GENETIC CONTROL OF THE IMMUNE RESPONSE TO HAPTEN-POLY-L-LYSINE CONJUGATES IN GUINEA PIGS.人工抗原的研究。III. 豚鼠对半抗原-聚-L-赖氨酸缀合物免疫反应的遗传控制。
J Exp Med. 1963 Dec 1;118(6):953-7. doi: 10.1084/jem.118.6.953.
10
STRUCTURE AND SPECIFICITY OF GUINEA PIG 7S ANTIBODIES.豚鼠7S抗体的结构与特异性
J Exp Med. 1963 Aug 1;118(2):229-44. doi: 10.1084/jem.118.2.229.

本文引用的文献

1
TYPING GROUP A HEMOLYTIC STREPTOCOCCI BY M PRECIPITIN REACTIONS IN CAPILLARY PIPETTES.用毛细吸管中的 M 沉淀反应对 A 组溶血性链球菌进行分型。
J Exp Med. 1943 Aug 1;78(2):127-33. doi: 10.1084/jem.78.2.127.
2
Hypersensitivity to penicillenic acid derivatives in human beings with penicillin allergy.对青霉素过敏的人类对青霉烯酸衍生物的超敏反应。
J Exp Med. 1962 Apr 1;115(4):821-38. doi: 10.1084/jem.115.4.821.
3
Polyfunctional dinitrophenyl haptens as reagents for elicitation of immediate type allergic skin responses.作为引发速发型过敏性皮肤反应试剂的多功能二硝基苯基半抗原
J Exp Med. 1962 Apr 1;115(4):789-801. doi: 10.1084/jem.115.4.789.
4
Antigenicity of polypeptides (poly-alpha-amino acids). II.多肽（聚α-氨基酸）的抗原性。II.
J Immunol. 1962 Mar;88:330-8.
5
Studies on the chemical basis of the antigenicity of proteins. 1. Antigenicity of polypeptidyl gelatins.蛋白质抗原性的化学基础研究。1. 多肽基明胶的抗原性。
Biochem J. 1960 Apr;75(1):91-102. doi: 10.1042/bj0750091.
6
[Electrophoresis on gelose and staining of the constituents].[琼脂糖凝胶电泳及成分染色]
Bull Soc Chim Biol (Paris). 1955;37(1):165-8.
7
Antibody formation in vitro.体外抗体形成。
J Exp Med. 1961 Dec 1;114(6):837-56. doi: 10.1084/jem.114.6.837.
8
Immunological specificity of delayed and immediate hypersensitivity reactions.迟发型和速发型超敏反应的免疫特异性
J Exp Med. 1962 May 1;115(5):1023-36. doi: 10.1084/jem.115.5.1023.
9
Studies on the chemical basis of the antigenicity of proteins. 2. Antigenic specificity of polytyrosyl gelatins.蛋白质抗原性的化学基础研究。2. 聚酪氨酰明胶的抗原特异性。
Biochem J. 1960 Apr;75(1):103-9. doi: 10.1042/bj0750103.
10
Studies on hypersensitivity. IV. The relationship between contact and delayed sensitivity: a study of the specificity of cellular immune reactions.超敏反应研究。IV. 接触性超敏反应与迟发型超敏反应之间的关系：细胞免疫反应特异性的研究
J Exp Med. 1961 Mar 1;113(3):571-85. doi: 10.1084/jem.113.3.571.

人工抗原的研究。I. 二硝基苯-聚赖氨酸及赖氨酸与谷氨酸的二硝基苯共聚物在豚鼠体内的抗原性

Studies on artifical antigens. I. Antigenicity of DNP-polylysine and DNP copolymer of lysine and glutamic acid in guinea pigs.

作者信息

KANTOR F S, OJEDA A, BENCARERRAF B

出版信息

J Exp Med. 1963 Jan 1;117(1):55-69. doi: 10.1084/jem.117.1.55.

DOI:10.1084/jem.117.1.55
PMID:14030666
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2180431/
Abstract

Dinitrophenyl conjugates of poly-L-lysine, varying in percentage conjugation and molecular weight have been found to induce skin reactivity and precipitating antibodies in guinea pigs. At best, 40 per cent of immunized animals developed delayed and immediate responses to DNP-polylysine, which is believed to reflect constitutional differences among the animals assayed. Only those animals capable of responding to DNP-polylysine, responded to an immunologically distinct poly-alpha-amino acid consisting of glutamyl and lysyl residues ("copolymer glu-lys"). The percentage of animals responding to the DNP-polylysine antigen decreased as the degree of DNP conjugation increased.

摘要

已发现不同偶联百分比和分子量的聚-L-赖氨酸二硝基苯基偶联物可在豚鼠中诱导皮肤反应性并产生沉淀抗体。最多有40%的免疫动物对二硝基苯基聚赖氨酸产生延迟和即时反应，这被认为反映了所检测动物之间的体质差异。只有那些能够对二硝基苯基聚赖氨酸作出反应的动物，才会对由谷氨酰基和赖氨酰基残基组成的免疫学上不同的聚α-氨基酸（“共聚物谷氨酰-赖氨酸”）作出反应。随着二硝基苯基偶联程度的增加，对二硝基苯基聚赖氨酸抗原作出反应的动物百分比下降。