Yamada M, Ogata M, Kawai M, Mashima Y
Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
Am J Ophthalmol. 2000 May;129(5):671-2. doi: 10.1016/s0002-9394(00)00415-3.
To determine whether substance P concentrations in tears reflect corneal hypesthesia.
Sixteen patients with unilateral corneal hypesthesia participated in this study. Unstimulated tears were collected from each eye of all subjects. Substance P concentrations in tears were measured by an enzyme immunoassay system.
Substance P concentrations in tears from the affected eye were lower than those in tears from the unaffected eye in all subjects. The mean concentration of substance P in tears from affected eyes was 197.7 +/- 69.5 pg/mL, markedly lower than those from unaffected eyes (333.2 +/- 74.6 pg/mL).
Substance P concentrations in tears, which are thought to reflect the neuropeptides levels in ocular tissues, can be used as an indicator of corneal denervation.
确定泪液中P物质浓度是否反映角膜感觉减退。
16名单侧角膜感觉减退患者参与本研究。收集所有受试者每只眼睛的非刺激泪液。采用酶免疫分析系统测量泪液中P物质浓度。
所有受试者患眼泪液中P物质浓度均低于未患眼。患眼泪液中P物质的平均浓度为197.7±69.5 pg/mL，明显低于未患眼（333.2±74.6 pg/mL）。
泪液中P物质浓度被认为反映眼组织中神经肽水平，可作为角膜去神经支配的指标。
