Kingsley R A, Bäumler A J
Department of Medical Microbiology and Immunology, 407 Reynolds Medical Building, College of Medicine, Texas A&M University System Health Science Center, College Station, TX 77843-1114, USA.
Mol Microbiol. 2000 Jun;36(5):1006-14. doi: 10.1046/j.1365-2958.2000.01907.x.
The recent emergence of food-borne pathogens, such as Salmonella enterica serotype Enteritidis (S. enteritidis) and Escherichia coli O157:H7, has generated increasing interest in how infectious diseases can invade, persist and spread within new host populations. To alter their host range pathogens require adaptations, which ensure their circulation in a new animal population. Adaptations for circulation in different populations of vertebrate hosts seem to have been acquired multiple times within the genus Salmonella because extant Salmonella serotypes differ greatly with regard to host range. In this article, mechanisms involved in host adaptation are deduced by considering the influence of the host immune response on circulation of Salmonella serotypes within populations of vertebrate animals. This approach contributes to the identification of genes involved in host adaptation and provides new insights into the emergence of food-borne pathogens.
最近出现的食源性病原体，如肠炎沙门氏菌肠炎血清型（肠炎沙门氏菌）和大肠杆菌O157:H7，引发了人们对传染病如何在新宿主群体中侵袭、持续存在和传播的日益浓厚的兴趣。为了改变其宿主范围，病原体需要进行适应性变化，以确保它们在新的动物群体中传播。在沙门氏菌属中，似乎多次获得了在不同脊椎动物宿主群体中传播的适应性变化，因为现存的沙门氏菌血清型在宿主范围方面差异很大。在本文中，通过考虑宿主免疫反应对沙门氏菌血清型在脊椎动物群体中传播的影响，推断出宿主适应性所涉及的机制。这种方法有助于识别参与宿主适应性的基因，并为食源性病原体的出现提供新的见解。
