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诊断和控制食源性人类病原体方面的公共卫生挑战概述

An Overview of the Public Health Challenges in Diagnosing and Controlling Human Foodborne Pathogens.

作者信息

Elbehiry Ayman, Abalkhail Adil, Marzouk Eman, Elmanssury Ahmed Elnadif, Almuzaini Abdulaziz M, Alfheeaid Hani, Alshahrani Mohammed T, Huraysh Nasser, Ibrahem Mai, Alzaben Feras, Alanazi Farhan, Alzaben Mohammed, Anagreyyah Sulaiman Abdulaziz, Bayameen Abdulraheem Mousa, Draz Abdelmaged, Abu-Okail Akram

机构信息

Department of Public Health, College of Public Health and Health Informatics, Qassim University, Al Bukayriyah 52741, Saudi Arabia.

Department of Bacteriology, Mycology and Immunology, Faculty of Veterinary Medicine, University of Sadat City, Sadat City 32511, Egypt.

出版信息

Vaccines (Basel). 2023 Mar 24;11(4):725. doi: 10.3390/vaccines11040725.


DOI:10.3390/vaccines11040725
PMID:37112637
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10143666/
Abstract

Pathogens found in food are believed to be the leading cause of foodborne illnesses; and they are considered a serious problem with global ramifications. During the last few decades, a lot of attention has been paid to determining the microorganisms that cause foodborne illnesses and developing new methods to identify them. Foodborne pathogen identification technologies have evolved rapidly over the last few decades, with the newer technologies focusing on immunoassays, genome-wide approaches, biosensors, and mass spectrometry as the primary methods of identification. Bacteriophages (phages), probiotics and prebiotics were known to have the ability to combat bacterial diseases since the turn of the 20th century. A primary focus of phage use was the development of medical therapies; however, its use quickly expanded to other applications in biotechnology and industry. A similar argument can be made with regards to the food safety industry, as diseases directly endanger the health of customers. Recently, a lot of attention has been paid to bacteriophages, probiotics and prebiotics most likely due to the exhaustion of traditional antibiotics. Reviewing a variety of current quick identification techniques is the purpose of this study. Using these techniques, we are able to quickly identify foodborne pathogenic bacteria, which forms the basis for future research advances. A review of recent studies on the use of phages, probiotics and prebiotics as a means of combating significant foodborne diseases is also presented. Furthermore, we discussed the advantages of using phages as well as the challenges they face, especially given their prevalent application in food safety.

摘要

食品中发现的病原体被认为是食源性疾病的主要原因;它们被视为一个具有全球影响的严重问题。在过去几十年里,人们对确定导致食源性疾病的微生物以及开发新的鉴定方法给予了大量关注。在过去几十年中,食源性病原体鉴定技术迅速发展,新技术主要集中在免疫测定、全基因组方法、生物传感器和质谱分析等鉴定方法上。自20世纪之交以来,人们就知道噬菌体、益生菌和益生元具有对抗细菌性疾病的能力。噬菌体的主要应用重点是医学治疗的发展;然而,其应用很快扩展到生物技术和工业的其他领域。对于食品安全行业也可以提出类似的观点,因为疾病直接危及消费者的健康。最近,由于传统抗生素的枯竭,人们对噬菌体、益生菌和益生元给予了大量关注。本研究的目的是回顾各种当前的快速鉴定技术。利用这些技术,我们能够快速鉴定食源性病原体,这为未来的研究进展奠定了基础。本文还综述了近期关于使用噬菌体、益生菌和益生元作为对抗重大食源性疾病手段的研究。此外,我们讨论了使用噬菌体的优势以及它们面临的挑战,特别是考虑到它们在食品安全中的广泛应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/227b/10143666/fdb4278f59d5/vaccines-11-00725-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/227b/10143666/1e53e7df162f/vaccines-11-00725-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/227b/10143666/18595fd0622e/vaccines-11-00725-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/227b/10143666/33392799495f/vaccines-11-00725-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/227b/10143666/fdb4278f59d5/vaccines-11-00725-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/227b/10143666/1e53e7df162f/vaccines-11-00725-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/227b/10143666/18595fd0622e/vaccines-11-00725-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/227b/10143666/33392799495f/vaccines-11-00725-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/227b/10143666/fdb4278f59d5/vaccines-11-00725-g004.jpg

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本文引用的文献

[1]
Foodborne illnesses of O157origin and its control measures.

J Food Sci Technol. 2023-4

[2]
Molecular Methods for Identification and Quantification of Foodborne Pathogens.

Molecules. 2022-11-26

[3]
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Vaccines (Basel). 2022-11-8

[4]
Recent Advances in the Application of Bacteriophages against Common Foodborne Pathogens.

Antibiotics (Basel). 2022-11-2

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Foods. 2022-10-5

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Crit Rev Food Sci Nutr. 2024

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Food Sci Biotechnol. 2022-9-1

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Crit Rev Biotechnol. 2023-12

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Front Microbiol. 2022-7-22

[10]
Antibacterial efficacy of lytic phages against multidrug-resistant Pseudomonas aeruginosa infections in bacteraemia mice models.

BMC Microbiol. 2022-8-1

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