Colin Ophélie, David Laure, Bailly Jean-Denis, Imazaki Pedro Henrique
Educational Unit on Food Hygiene and Industry, Université de Toulouse, ENVT, Toulouse, France.
IRSD, Université de Toulouse, INSERM, INRAE, ENVT, UPS, Toulouse, France.
AIMS Microbiol. 2025 Apr 14;11(2):295-317. doi: 10.3934/microbiol.2025014. eCollection 2025.
Food safety is a major public health concern. The zoonotic pathogen non-typhoidal , responsible for salmonellosis, is a leading cause of bacterial food poisoning globally, making its detection and control essential. Understanding the infectious dose of is crucial for identifying appropriate risk management strategies; however, significant uncertainties remain, warranting a systematic review. Following PRISMA guidelines, we conducted a comprehensive search across multiple databases (Web of Science, PubMed, and CAB Abstracts) to identify relevant studies examining the relationship between dose and foodborne illness in humans. Four main types of studies were identified: experimental trials, case reports, case series, and mathematical modelling. An analysis of these studies revealed their respective strengths and limitations. The data showed considerable variability, with the dose required to cause illness depending on factors such as serovar, food type, and the health status of the exposed population. A key challenge identified was the lack of sufficient data on collective food poisoning incidents, which complicates the development of more reliable dose-response models. Despite these limitations, this review underscores the importance of targeted food safety interventions and risk assessments tailored to specific food products and population groups. The findings provide a foundation for enhanced food safety measures and support ongoing efforts to protect public health from foodborne illnesses.
食品安全是一个重大的公共卫生问题。人畜共患病原体非伤寒沙门氏菌是导致沙门氏菌病的病原体，是全球细菌性食物中毒的主要原因，因此对其进行检测和控制至关重要。了解非伤寒沙门氏菌的感染剂量对于确定适当的风险管理策略至关重要；然而，仍存在重大不确定性，需要进行系统综述。按照PRISMA指南，我们在多个数据库（科学网、PubMed和CAB文摘库）中进行了全面检索，以识别研究非伤寒沙门氏菌剂量与人类食源性疾病之间关系的相关研究。确定了四种主要类型的研究：实验性试验、病例报告、病例系列和数学建模。对这些研究的分析揭示了它们各自的优势和局限性。数据显示出相当大的变异性，致病所需的剂量取决于非伤寒沙门氏菌血清型、食物类型和暴露人群的健康状况等因素。确定的一个关键挑战是缺乏关于集体食物中毒事件的足够数据，这使得开发更可靠的剂量反应模型变得复杂。尽管存在这些局限性，但本综述强调了针对特定食品和人群的有针对性的食品安全干预措施和风险评估的重要性。这些发现为加强食品安全措施提供了基础，并支持正在进行的保护公众健康免受食源性疾病侵害的努力。
