Jacobs L, Kinkel W
Neurology. 1976 Jun;26(6 PT 1):501-7. doi: 10.1212/wnl.26.6.501.
Twenty patients with normal pressure hydrocephalus were examined by computerized axial transverse tomographic (CT) scanning and the results were compared with pneumoencephalographic findings and clinical responses to ventricular shunting. The CT scan revealed significant cortical atrophy, not demonstrated by pneumoencephalogram in seven patients. The cortical atrophy was confirmed by autopsy in one case. This examination also revealed greatly enlarged ventricles (25 to 40 per cent of intracranial volume) in eight patients up to 4 years after ventricular shunting. There was no relationship between the presence or absence of cortical atrophy, or the postoperative ventricular size, and the clinical responses to ventricular shunting. Current concepts of normal pressure hydrocephalus must be revised in view of these findings.
对20例正常压力脑积水患者进行了计算机轴向断层扫描（CT）检查，并将结果与气脑造影结果以及脑室分流术的临床反应进行了比较。CT扫描显示有明显的皮质萎缩，7例患者的气脑造影未显示此情况。其中1例经尸检证实存在皮质萎缩。该检查还显示，8例患者在脑室分流术后长达4年的时间里脑室大幅扩大（占颅内体积的25%至40%）。皮质萎缩的有无、术后脑室大小与脑室分流术的临床反应之间均无关联。鉴于这些发现，必须对正常压力脑积水的现有概念进行修正。
