Acaba L, Hallman D, Rodríguez-Morales E, Vélez R, Vélez-García E
Department of Medicine, University of Puerto Rico School of Medicine, San Juan 00936-5067.
Bol Asoc Med P R. 2000 Jan-Mar;92(1-3):12-4.
Chronic lymphocytic leukemia (CLL) is a chronic, low-grade hematologic malignancy that can transform to a large cell non-Hodgkin's lymphoma (Richter's syndrome), which is associated with an unfavorable prognosis. A distinct Hodgkin's disease subgroup of lymphomatous CLL transformation has been well characterized. We describe a patient presenting with simultaneous manifestations of CLL and Hodgkin's disease. This patient is unique, presenting with separate sites of involvement of each disease within the same organ, in this case the bone marrow. The morphologic and immunohistochemical findings at diagnosis are correlated with the findings of the postmortem examination.
慢性淋巴细胞白血病（CLL）是一种慢性、低度血液系统恶性肿瘤，可转化为大细胞非霍奇金淋巴瘤（里氏综合征），其预后不良。淋巴瘤性CLL转化的一个独特霍奇金病亚组已得到充分描述。我们报告一例同时出现CLL和霍奇金病表现的患者。该患者很独特，同一器官（本例为骨髓）内每种疾病有各自不同的受累部位。诊断时的形态学和免疫组化结果与尸检结果相关。
