与石棉暴露相关的结节性肺淀粉样变性

Nodular pulmonary amyloidosis associated with asbestos exposure.

作者信息

Hiroshima K, Ohwada H, Ishibashi M, Yamamoto N, Tamiya N, Yamaguchi Y

机构信息

Division of Pathology, School of Medicine, Chiba University, Japan.

出版信息

Pathol Int. 1996 Jan;46(1):66-70. doi: 10.1111/j.1440-1827.1996.tb03535.x.

DOI:10.1111/j.1440-1827.1996.tb03535.x

PMID:10846552

Abstract

A 71 year old man was admitted for the purpose of diagnosis of a right solitary pulmonary nodule. The size of the nodule was 18 x 18 mm in diameter 2 years ago, but it has become large, 25 x 25 mm in diameter. The nodule was resected by thoracotomy. Microscopically, eosinophilic amorphous, acellular substances were surrounded by inflammatory infiltrates. It stained with Congo red stain and showed green birefringence with polarizing microscopy. Amyloid fibrils were observed electron microscopically. Asbestos bodies were observed in the lung parenchyma around the nodule. This case shows that a nodule in nodular pulmonary amyloidosis can grow gradually and suggests the possibility of asbestos fibers as one of the etiologic factors in nodular pulmonary amyloidosis.

摘要

一名71岁男性因诊断右肺孤立性结节入院。该结节两年前直径为18×18毫米，但现已增大，直径达25×25毫米。通过开胸手术切除了该结节。显微镜下，嗜酸性无定形、无细胞物质被炎性浸润包围。其经刚果红染色，在偏振显微镜下呈现绿色双折射。电镜下观察到淀粉样纤维。在结节周围的肺实质中观察到石棉小体。该病例表明，结节性肺淀粉样变中的结节可逐渐生长，并提示石棉纤维作为结节性肺淀粉样变病因之一的可能性。