Kühner C
Zentralinstitut für Seelische Gesundheit, Mannheim.
Nervenarzt. 2000 May;71(5):393-400. doi: 10.1007/s001150050574.
The present study examines episode characteristics in unipolar psychotic depression. From a sample of unipolar endogenous depressed inpatients, patients with a psychotic index episode (n = 19) were compared to nonpsychotic patients (n = 86) with regard to case history, characteristics of the inpatient episode, residual symptoms at discharge from hospital and course of illness up to seven months after discharge. Psychotic depressed patients displayed more severe observer-rated depressive symptoms at admission and were more likely to have attempted suicide prior to admission. In the post-discharge short-term course of depression, these patients showed a more pronounced symptom homogeneity in the extreme ranges, which occurred by stable remissions or by prolonged symptomatology in need of treatment. These findings, together with the observation of higher stabilities of symptom scores in the psychotically depressed, emphasize the prognostic significance of symptomatology at discharge to the post-discharge episode course in these patients.
本研究考察了单相精神病性抑郁症的发作特征。从单相内源性抑郁住院患者样本中,将有精神病性指数发作的患者(n = 19)与非精神病性患者(n = 86)在病史、住院发作特征、出院时残留症状以及出院后长达七个月的病程方面进行了比较。精神病性抑郁患者入院时表现出更严重的由观察者评定的抑郁症状,且入院前更有可能尝试过自杀。在出院后的短期抑郁病程中,这些患者在极端范围内表现出更明显的症状同质性,这是通过稳定缓解或需要治疗的长期症状表现出现的。这些发现,连同对精神病性抑郁患者症状评分更高稳定性的观察,强调了出院时症状学对这些患者出院后发作病程的预后意义。