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新生期胸腺切除的高反应和低反应大鼠对聚（谷氨酸52-赖氨酸33-酪氨酸15）免疫反应的遗传控制

Genetic control of the immune response to poly(Glu52Lys33Tyr15) in neonatally thymectomized high and low responder rats.

作者信息

Davis B K, Shonnard J W, Gill T J

出版信息

Am J Pathol. 1976 Jul;84(1):55-68.

PMID:1084697
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2032349/
Abstract

The immune response to poly (Glu52Lys33Tyr15) is under polygenic control and linked to the major histocompatibility complex of the rat. Aggregation of this antigen with methylated bovine serum albumin (MeBSA) eliminates the expression of genetic control by increasing the response of low responders and decreasing that of high responders. Humoral and cellular aspects of the immune response to both unaggregated and aggregated poly (Glu52Lys33Tyr15) were investigated in neonatally thymectomized high-responder ACI and low-responder F344 rats. T cells are necessary for responses to unaggregated poly (Glu52Lys33Tyr15) since thymectomy significantly decreased numbers of antibody-forming cells and serum antibody levels, and delayed hypersensitivity responses and antigen-induced in vitro proliferation. However, thymectomy had no significant effect on these parameters of immune responsiveness in either ACI or F344 rats immunized with poly (Glu52Lys33Tyr15)/MeBSA. Aggregation also increased IgG production and delayed hypersensitivity and antibody affinity in low responders.

摘要

对聚（谷氨酸52-赖氨酸33-酪氨酸15）的免疫反应受多基因控制，并与大鼠的主要组织相容性复合体相关。该抗原与甲基化牛血清白蛋白（MeBSA）聚集，通过增加低反应者的反应并降低高反应者的反应，消除了遗传控制的表达。在新生期胸腺切除的高反应性ACI大鼠和低反应性F344大鼠中，研究了对未聚集和聚集的聚（谷氨酸52-赖氨酸33-酪氨酸15）的免疫反应的体液和细胞方面。T细胞对于对未聚集的聚（谷氨酸52-赖氨酸33-酪氨酸15）的反应是必需的，因为胸腺切除显著降低了抗体形成细胞的数量和血清抗体水平，并延迟了超敏反应和抗原诱导的体外增殖。然而，胸腺切除对用聚（谷氨酸52-赖氨酸33-酪氨酸15）/MeBSA免疫的ACI或F344大鼠的这些免疫反应参数没有显著影响。聚集还增加了低反应者的IgG产生、延迟超敏反应和抗体亲和力。

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Quantitative micro-method for measuring antibody utilizing the bromoacetyl cellulose immunoadsorbant.利用溴乙酰纤维素免疫吸附剂测定抗体的定量微量方法。
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Thymus dependence of antibody response: variation with dose of antigen and class of antibody.抗体反应的胸腺依赖性：随抗原剂量和抗体类别而变化
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Neonatal thymectomy and the decrease in antigen-sensitivity of the primary response and immunological "memory" systems.新生儿胸腺切除与初次反应及免疫“记忆”系统抗原敏感性的降低
Immunology. 1968 Sep;15(3):325-33.
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Further improvements in the plaque technique for detecting single antibody-forming cells.用于检测单个抗体形成细胞的蚀斑技术的进一步改进。
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