Increase in E-rosettes after transfer factor (TF) treatment: fractionation of TF.

The effect of transfer factor (TF) on E-rosettes (ER) was studied in vivo in a patient with Hodgkin's disease. Transfer factor was given in doses of 10 units/sq m intramuscularly. The ER forming cells and the ER scores were determined. The ER score method took into account the number of erythrocytes in each rosette. The increase in ER score was maximum at 24 hours and it declined during the following one to two weeks. It was suggested that TF may have to be given more frequently than indicated by the persistence of skin reactivity. TF was fractionated with high pressure liquid chromatography. Fraction 2 increased ER in a patient with Schwannoma. Non-specificity of TF was also discussed.