Hogan R E, Bucholz R D, Choudhuri I, Mark K E, Butler C S, Joshi S
Department of Neurology, Saint Louis University, MO 63110, USA.
J Digit Imaging. 2000 May;13(2 Suppl 1):39-42. doi: 10.1007/BF03167621.
Structural hippocampal magnetic resonance (MR) imaging-based analysis is helpful in the diagnosis and treatment of mesial temporal epileptic seizures. Computational anatomic techniques provide a framework for objective assessment of three-dimensional hippocampal structure. We applied a previously validated technique of deformation-based hippocampal segmentations in 20 subjects with documented unilateral mesial temporal sclerosis (MTS) and temporal lobe epilepsy. Using composite images, we then measured shape differences between the epileptogenic, smaller hippocampus, and contralateral hippocampus. Final shape differences were projected on the contralateral "normal" side. We calculated results for the left MTS group (10 patients) and right MTS group (10 patients) separately. Both groups showed similar regions of maximal inward deformation in the affected hippocampus, which were the medial and lateral aspect of the head, and posterior aspect of the tail. These results suggest that there are specific three-dimensional patterns of volume loss in patients with mesial temporal epilepsy.
基于海马结构磁共振成像的分析有助于内侧颞叶癫痫发作的诊断和治疗。计算解剖学技术为客观评估三维海马结构提供了一个框架。我们将一种先前经过验证的基于变形的海马分割技术应用于20名有单侧内侧颞叶硬化（MTS）和颞叶癫痫记录的受试者。然后，我们使用合成图像测量致痫性较小海马与对侧海马之间的形状差异。最终的形状差异投影到对侧“正常”侧。我们分别计算了左侧MTS组（10例患者）和右侧MTS组（10例患者）的结果。两组在受影响海马中均显示出相似的最大向内变形区域，分别为头部的内侧和外侧以及尾部的后部。这些结果表明，内侧颞叶癫痫患者存在特定的三维体积丢失模式。
