Jack C R, Petersen R C, Xu Y, O'Brien P C, Smith G E, Ivnik R J, Tangalos E G, Kokmen E
Department of Diagnostic Radiology, Mayo Clinic and Foundation, Rochester, MN 55905, USA.
Neurology. 1998 Oct;51(4):993-9. doi: 10.1212/wnl.51.4.993.
To determine the annual rates of volumetric change of the hippocampus and temporal horn in cognitively normal elderly control subjects and individually matched patients with AD, and to test the hypothesis that these rates were different.
Cross-sectional studies consistently reveal cerebral atrophy in elderly nondemented subjects compared with healthy young adults, and greater atrophy in patients with AD relative to elderly control subjects. However, rates of atrophy are estimated most accurately by performing serial measurements in the same individuals.
MRI-based volumetric measurements of the hippocampi and temporal horns were performed in 24 cognitively normal subjects aged 70 to 89 years who were individually matched with respect to gender and age with 24 patients with AD. Each subject underwent an MRI protocol twice, separated by 12 months or more.
The mean annual rate of hippocampal volume loss among control subjects was -1.55+/-1.38% and the temporal horns increased in volume by 6.15+/-7.69% per year. These rates were significantly greater among AD patients: hippocampus, -3.98+/-1.92% per year, p < 0.001; temporal horn, 14.16+/-8.47% per year, p = 0.002.
A statistically significant yearly decline in hippocampal volume and an increase in temporal horn volume was identified in elderly control subjects who represent typical aging individuals. These rates were approximately 2.5 times greater in patients with AD than in individually age- and gender-matched control subjects.
确定认知正常的老年对照受试者以及年龄和性别相匹配的阿尔茨海默病（AD）患者海马体和颞角的年体积变化率，并检验两者变化率不同的假设。
横断面研究一致显示，与健康的年轻成年人相比，老年非痴呆受试者存在脑萎缩，且AD患者的萎缩程度相对于老年对照受试者更大。然而，通过对同一组个体进行连续测量能最准确地估计萎缩率。
对24名年龄在70至89岁的认知正常受试者进行基于磁共振成像（MRI）的海马体和颞角体积测量，这些受试者在性别和年龄上与24名AD患者一一匹配。每位受试者接受两次MRI检查，间隔12个月或更长时间。
对照受试者海马体体积的年均丢失率为-1.55±1.38%，颞角体积每年增加6.15±7.69%。AD患者的这些变化率明显更大：海马体，每年-3.98±1.92%，p<0.001；颞角，每年14.16±8.47%，p = 0.002。
在代表典型衰老个体的老年对照受试者中，发现海马体体积每年有统计学意义的下降，颞角体积增加。AD患者的这些变化率约为年龄和性别匹配的对照受试者的2.5倍。
