Heather B P, Poskitt K R, Earnshaw J J, Whyman M, Shaw E
Gloucestershire Royal Hospital, Gloucester and Cheltenham General Hospital, Cheltenham, UK.
Br J Surg. 2000 Jun;87(6):750-3. doi: 10.1046/j.1365-2168.2000.01476.x.
Rupture of an unsuspected abdominal aortic aneurysm is a major cause of death in men over the age of 65 years. A significant reduction in deaths is likely to result only from higher rates of detection and increased numbers of elective aneurysm repairs. Screening of men reaching the age of 65 years has been taking place in the county of Gloucestershire, UK since 1990 and the aim of this study was to investigate any change in the mortality rate from aortic aneurysm in the screened portion of the population.
Total number of deaths from all aortic aneurysm-related causes in the county's population was calculated from hospital and post-mortem records, together with computerized death certificate records, for the years 1994-1998. The overall number of aneurysm-related deaths in men aged 65-73 years, who have been progressively influenced by the screening programme, was compared with that for men of all other ages.
The total number of aneurysm-related deaths in men aged 65-73 years decreased progressively year by year between 1994 and 1998; this reduction is highly statistically significant (P < 0. 001). No such change was observed in the unscreened part of the population.
Screening for asymptomatic abdominal aortic aneurysm results in a significant reduction in numbers of deaths from all aneurysm-related causes in the screened portion of the male population.
未被察觉的腹主动脉瘤破裂是65岁以上男性死亡的主要原因。只有提高检测率和增加择期动脉瘤修复手术数量，才有可能显著降低死亡率。自1990年以来，英国格洛斯特郡一直在对年满65岁的男性进行筛查，本研究的目的是调查在接受筛查的人群中，主动脉瘤死亡率是否有任何变化。
根据1994年至1998年的医院记录、尸检记录以及计算机化死亡证明记录，计算该郡人口中所有与主动脉瘤相关原因导致的死亡总数。将逐渐受到筛查计划影响的65至73岁男性中与动脉瘤相关的死亡总数，与所有其他年龄段男性的死亡总数进行比较。
1994年至1998年间，65至73岁男性中与动脉瘤相关的死亡总数逐年逐渐下降；这种下降在统计学上具有高度显著性（P < 0.001）。在未接受筛查的人群中未观察到此类变化。
对无症状腹主动脉瘤进行筛查可使接受筛查的男性人群中所有与动脉瘤相关原因导致的死亡人数显著减少。
