Shepherd N A
Department of Histopathology, Gloucestershire Royal Hospital, Gloucester, UK.
Histopathology. 2000 Jun;36(6):559-62. doi: 10.1046/j.1365-2559.2000.0954b.x.
Muciphages (mucin-containing macrophages), first described in 1966 by Azzopardi & Evans, are a common feature of biopsies of large intestinal mucosa, even in the absence of other abnormalities such as active inflammation or evidence of chronic inflammatory bowel disease. Should they be mentioned in diagnostic reports? Do muciphages reliably indicate previous mucosal disease, now quiescent? In the following articles, Salto-Tellez & Price review what is known about muciphages and conclude that they reflect previous occult and clinically unimportant mucosal damage and that, in an otherwise normal colorectal mucosa, they have no diagnostic significance; and Shepherd draws attention to a wide range of clinically much more significant mucosal infiltrates that could be mistakenly regarded as muciphages and thus overlooked.
黏液吞噬细胞（含黏液的巨噬细胞）由阿佐帕迪和埃文斯于1966年首次描述，是大肠黏膜活检的常见特征，即便不存在其他异常情况，如活动性炎症或慢性炎症性肠病的证据。诊断报告中是否应提及它们？黏液吞噬细胞能否可靠地表明既往存在的现已静止的黏膜疾病？在以下文章中，萨尔托 - 特列斯和普赖斯回顾了关于黏液吞噬细胞的已知情况，并得出结论：它们反映了既往隐匿且临床上无重要意义的黏膜损伤，并且在其他方面正常的结直肠黏膜中，它们没有诊断意义；而谢泼德提请注意一系列临床上更具重要意义的黏膜浸润，这些浸润可能会被错误地视为黏液吞噬细胞从而被忽视。
