Glorio R, Allevato M, De Pablo A, Abbruzzese M, Carmona L, Savarin M, Ibarra M, Busso C, Mordoh A, Llopis C, Haas R, Bello M, Woscoff A
Division Dermatologic, Hospital de Clínicas "José de San Martín," Buenos Aires, Argentina.
Int J Dermatol. 2000 May;39(5):348-53. doi: 10.1046/j.1365-4362.2000.00924.x.
Eating disorders are increasing and show a variety of symptoms. They mainly include anorexia nervosa (AN), bulimia nervosa (BN), and eating disorders not specified (EDNOS). They predominate in females and represent an important danger, especially in teenagers. In serious cases, they may be life-threatening. Objective To determine the prevalence of cutaneous findings in patients with eating disorders and to compare the results with those found in the literature.
An observational, transverse, and prospective study was performed. Two hundred patients of recent admission to ALUBA (association that fights against BN and AN), a psychiatric unit for eating disorders, were included: 122 BN; 62 AN; 16 EDNOS.
Patients with eating disorders show dermatologic manifestations (alopecia, xerosis, hypertrichosis, caries, nail fragility) that are secondary to starvation. Russell's sign, seen as calluses on the dorsal aspect of the hands, is a consequence of self-induced vomiting and the local trauma of the superior incisors. This sign represents a compensatory behavior to overeating and predominates in the BN group.
The recognition of dermatologic signs could be of immense value and could lead to the early diagnosis and treatment of these eating disorders.
饮食失调症的发病率正在上升，且表现出多种症状。主要包括神经性厌食症（AN）、神经性贪食症（BN）和未特定的饮食失调症（EDNOS）。这些疾病在女性中占主导地位，是一个重大危险因素，尤其是在青少年中。在严重情况下，可能会危及生命。目的：确定饮食失调症患者皮肤表现的患病率，并将结果与文献中的数据进行比较。
进行了一项观察性、横断面和前瞻性研究。纳入了200名刚入住ALUBA（一个对抗BN和AN的协会）饮食失调症精神科病房的患者：122名BN患者；62名AN患者；16名EDNOS患者。
饮食失调症患者表现出因饥饿继发的皮肤表现（脱发、皮肤干燥、多毛症、龋齿、指甲脆弱）。拉塞尔征表现为手部背侧的胼胝，是自我诱导呕吐和上门牙局部创伤的结果。该体征是暴饮暴食的一种代偿行为，在BN组中占主导。
认识皮肤体征可能具有巨大价值，并可导致这些饮食失调症的早期诊断和治疗。
