Tyler Ingrid, Wiseman Marni C, Crawford Richard I, Birmingham C Laird
University of British Columbia, Vancouver, British Columbia, Canada.
J Cutan Med Surg. 2002 Jul-Aug;6(4):345-53. doi: 10.1177/120347540200600407. Epub 2002 Apr 15.
No complete review of the cutaneous manifestations of eating disorders exists. We therefore, set out to review and systematically describe the clinical and histopathologic features of dermatologic conditions associated with anorexia nervosa, bulimia nervosa, and obesity. Differential diagnosis, pathophysiology, laboratory studies, and treatment are also reviewed.
Index Medicus review (1966 to present) using Ovid-MEDLINE. Search terms included eating disorders, anorexia nervosa, bulimia nervosa, eating disorders not otherwise specified (ED-NOS), and obesity, as well as the terms dermatology skin and cutaneous manifestations, with cross-referencing sources. These were combined with our own clinical experience. All relevant publications, including case reports, case series, cohort studies, and histopathologic studies giving at least Level II-3 evidence (evidence from comparisons between times or places with or without the intervention, including dramatic results in uncontrolled experiments), were selected.
Forty dermatological signs have been reported in eating disorder patients. Eating disorders have many cutaneous manifestations and cutaneous signs may lead to the diagnosis of an occult eating disorder. The resolution of skin eruptions in eating disorder patients often depends on treatment of the underlying disorder.
目前尚无关于饮食失调皮肤表现的全面综述。因此，我们着手回顾并系统描述与神经性厌食症、神经性贪食症和肥胖症相关的皮肤病的临床和组织病理学特征。同时也对鉴别诊断、病理生理学、实验室检查及治疗进行了综述。
使用Ovid-MEDLINE对医学索引（1966年至今）进行检索。检索词包括饮食失调、神经性厌食症、神经性贪食症、未另行规定的饮食失调（ED-NOS）、肥胖症，以及皮肤病学、皮肤和皮肤表现等术语，并交叉引用相关文献。这些检索结果结合了我们自身的临床经验。所有相关出版物，包括病例报告、病例系列、队列研究和组织病理学研究，只要提供至少II-3级证据（来自有或无干预的不同时间或地点之间比较的证据，包括非对照实验中的显著结果），均被选中。
饮食失调患者已报告有40种皮肤体征。饮食失调有许多皮肤表现，皮肤体征可能有助于诊断隐匿性饮食失调。饮食失调患者皮肤疹的消退通常取决于潜在疾病的治疗。
