Kamel E G, McNeill G, Van Wijk M C
Department of Medicine & Therapeutics, University of Aberdeen, Aberdeen AB25 2ZD, UK.
Int J Obes Relat Metab Disord. 2000 May;24(5):607-13. doi: 10.1038/sj.ijo.0801204.
To compare the changes in intra-abdominal adipose tissue (IAAT) measured by magnetic resonance imaging (MRI) with changes in central abdominal fat (CAF) measured by dual-energy X-ray absorptiometry (DXA) and anthropometric measurements in obese subjects before and after a weight loss programme.
Longitudinal, clinical intervention study of a 600 kcal/day deficit diet with 10 mg/day sibutramine per day for six months.
Nineteen women (age: 42+/-8.7 y, BMI: 33.3+/-1.9 kg/m2) and 17 men (age: 41.8+/-5.3 y, BMI: 32.6+/-2.4 kg/m2).
MRI was used to measure the effect of weight loss on IAAT. Changes in IAAT were compared with changes in CAF by DXA and anthropometry.
The percentage of changes in IAAT was greater than that in subcutaneous adipose tissue (SCAT) in both women and men (P<0.01). Changes in IAAT were significantly correlated with changes in weight and BMI in both women and men. In women and not in men, changes in CAF by DXA, waist circumference and WHR were also significantly correlated with the changes in IAAT.
Estimation of the change in IAAT was better in obese women than obese men. In both sexes the changes in weight and BMI had the highest correlation coefficients with the change in IAAT.
比较肥胖受试者在减肥计划前后，通过磁共振成像（MRI）测量的腹内脂肪组织（IAAT）变化与通过双能X线吸收法（DXA）测量的腹部中央脂肪（CAF）变化以及人体测量学指标变化。
一项纵向临床干预研究，采用每天600千卡热量 deficit 饮食并每天服用10毫克西布曲明，为期六个月。
19名女性（年龄：42±8.7岁，体重指数：33.3±1.9千克/平方米）和17名男性（年龄：41.8±5.3岁，体重指数：32.6±2.4千克/平方米）。
使用MRI测量减肥对IAAT的影响。将IAAT的变化与通过DXA和人体测量学测得的CAF变化进行比较。
女性和男性的IAAT变化百分比均大于皮下脂肪组织（SCAT）的变化百分比（P<0.01）。女性和男性的IAAT变化均与体重和体重指数的变化显著相关。在女性而非男性中，通过DXA测得的CAF变化、腰围和腰臀比（WHR）也与IAAT变化显著相关。
肥胖女性IAAT变化的估计比肥胖男性更好。在两性中，体重和体重指数的变化与IAAT变化的相关系数最高。
