Karpocheva S V, Kostinov M P, Zaeva G E, Gurvich E B, Zaĭtseva L A, Gavrilova G L, Korotkova O V, Kuznetsova A V
Mechnikov Research Institute for Vaccines and Sera, Research Institute of Child Oncology and Hematology, Moscow, Russia.
Zh Mikrobiol Epidemiol Immunobiol. 1999 Jul-Aug(4):46-9.
Data on the safety and effect of the vaccination of children with solid tumors are presented. As revealed in this study, the injection of adsorbed DT-m toxoid with reduced antigen content at the period of remission does not induce the relapse of the disease and leads to the production of specific antitoxic antibodies on the protective level. The study has shown that complex antitumor treatment does not essentially affect the formation of specific immune response, though prolonged changes in cell-mediated immunity can be observed.