Maksimova N M, Basova N N, Sukhorukova N L, Finkel' M P
Zh Mikrobiol Epidemiol Immunobiol. 1987 Jun(6):43-6.
After primary immunization with adsorbed DPT vaccine antitetanus immunity was retained for 9-10 years in 90.6-98.4% of children covered by this study. The second booster immunization of children against tetanus with adsorbed DT toxoid with reduced antigen content, made at an interval prolonged to 7-10 years under the conditions of lower antitoxic immunity, ensured a high level of intense antitetanus immunity. These data point to the possibility of prolonging the interval between booster immunizations to 9-10 years and reducing the number of injections and antigenic load.
在本研究涵盖的儿童中,接种吸附百白破疫苗进行初次免疫后,90.6% - 98.4%的儿童破伤风免疫力可维持9至10年。在抗毒素免疫力较低的情况下,以间隔7至10年的时间对儿童进行第二次破伤风加强免疫,使用抗原含量降低的吸附破伤风类毒素,可确保高水平的强烈破伤风免疫力。这些数据表明,有可能将加强免疫的间隔延长至9至10年,并减少注射次数和抗原负荷。