Chudnaia L M, Oksiiuk V G, Shekhter A B, Krasiuk L S, Afanas'eva S M, Bryzhata S I, Kozhan N E, Chaban E P
Zh Mikrobiol Epidemiol Immunobiol. 1991 Jan(1):46-9.
The work was aimed at the comparative study of the intensity of immunity to diphtheria, tetanus and poliomyelitis, depending on the number of injections of adsorbed diphtheria-pertussis-tetanus (DPT) vaccine and poliomyelitis vaccine, for the purpose of finding out the possibility of reducing the antigenic load given to children without diminishing the intensity of immunity. To determine the level of immunity to diphtheria and tetanus, 1900 children under school age were serologically studied by the micromethod in the passive hemagglutination test. The intensity of immunity to poliomyelitis virus was studied in 333 children by means of the neutralization test. The immunogenic properties of the diphtheria component of adsorbed DPT vaccine were found to be less pronounced than those of the tetanus component of the vaccine, which made it impossible to reduce the antigenic load by decreasing the number of vaccinations against diphtheria. The results of the study of postvaccinal immunity to poliomyelitis suggest that during the first and second year of life the course of vaccination against poliomyelitis may be reduced to 3 injections.
这项工作旨在比较白喉、破伤风和脊髓灰质炎的免疫强度，该强度取决于吸附型白喉-百日咳-破伤风（DPT）疫苗和脊髓灰质炎疫苗的注射次数，目的是找出在不降低免疫强度的情况下减少给予儿童的抗原负荷的可能性。为了确定对白喉和破伤风的免疫水平，采用被动血凝试验的微量法对1900名学龄前儿童进行了血清学研究。通过中和试验对333名儿童的脊髓灰质炎病毒免疫强度进行了研究。发现吸附型DPT疫苗的白喉成分的免疫原性不如该疫苗的破伤风成分明显，这使得无法通过减少白喉疫苗接种次数来降低抗原负荷。对脊髓灰质炎疫苗接种后免疫的研究结果表明，在生命的第一年和第二年，脊髓灰质炎疫苗接种疗程可减至3次注射。
