Zaporzhets T S, Lunika I G, Greben'kova L K, Belogolovkina N A, Makarenkova I D, Besednova N N
Research Institute of Epidemiology and Microbiology, Head Office of Public Health of the Administration of the Maritime Territory, Vladivostok, Russia.
Zh Mikrobiol Epidemiol Immunobiol. 1999 Mar-Apr(2):57-9.
The state of collective immunity to diphtheria and tetanus in children of preschool age, depending on the kind of vaccine preparation used for immunization, was studied. The immunological potency of adsorbed DPT vaccine (i.e. its capacity of forming prolonged and stable basic immunity) was shown to be higher in comparison with the potency of adsorbed DT toxoid with reduced antigen content (DT-R). The study revealed that in all groups of children the level of antitetanus immunity was higher than the level of antidiphtheria immunity, and 3 years later its decrease was less pronounced. A stricter approach to giving medical grounds for the use of low-reactive adsorbed DT-R in the immunization of children belonging to groups of risk is recommended.
研究了学龄前儿童对白喉和破伤风的群体免疫状况，该状况取决于用于免疫的疫苗制剂类型。结果显示，与抗原含量降低的吸附破伤风类毒素（DT-R）相比，吸附百白破疫苗的免疫效力（即其形成持久稳定基础免疫的能力）更高。研究发现，在所有儿童组中，抗破伤风免疫力水平高于抗白喉免疫力水平，且3年后其下降不太明显。建议在为属于风险组的儿童进行免疫接种时，采用更严格的方法为使用低反应性吸附DT-R提供医学依据。
