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对体内和体外淋巴细胞脉络丛脑膜炎病毒感染的免疫反应。免疫介导疾病的机制。

Immune responses to LCM virus infection in vivo and in vitro. Mechanisms of immune-mediated disease.

作者信息

Cole G A, Johnson E D

出版信息

Bull World Health Organ. 1975;52(4-6):465-70.

PMID:1085206
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2366627/
Abstract

Both recovery and death of mice following acute infections with lymphocytic choriomeningitis virus appear to be mediated by a population of virus-specific thymus-derived (T) effector lymphocytes that possess lytic activity in vitro against virus-infected syngeneic fibroblasts. Whether recovery or death occurs is determined by the balance between two interdependent factors: (1) the extent of virus-induced modifications in the surfaces of cells comprising "target" tissues, and (2) the efficiency of the immune inductive process leading to the generation of effector T lymphocytes that recognize and destroy these modified cells.

摘要

小鼠感染淋巴细胞性脉络丛脑膜炎病毒后，恢复或死亡似乎都由一群病毒特异性胸腺来源（T）效应淋巴细胞介导，这些细胞在体外对病毒感染的同基因成纤维细胞具有裂解活性。恢复或死亡的发生取决于两个相互依存因素之间的平衡：（1）病毒诱导的构成“靶”组织的细胞表面修饰程度，以及（2）导致产生识别并破坏这些修饰细胞的效应T淋巴细胞的免疫诱导过程的效率。

相似文献

1
Immune responses to LCM virus infection in vivo and in vitro. Mechanisms of immune-mediated disease.对体内和体外淋巴细胞脉络丛脑膜炎病毒感染的免疫反应。免疫介导疾病的机制。
Bull World Health Organ. 1975;52(4-6):465-70.
2
Functional heterogeneity of lymphocytic choriomeningitis virus-specfic T lymphocytes. I. Identification of effector amd memory subsets.淋巴细胞性脉络丛脑膜炎病毒特异性T淋巴细胞的功能异质性。I. 效应细胞和记忆亚群的鉴定。
J Exp Med. 1975 Apr 1;141(4):866-81.
3
The immune response of the mouse to lymphocytic choriomeningitis virus. V. High numbers of cytolytic T lymphocytes are generated in the spleen during acute infection.小鼠对淋巴细胞性脉络丛脑膜炎病毒的免疫反应。V. 急性感染期间脾脏中产生大量细胞毒性T淋巴细胞。
Eur J Immunol. 1987 Jul;17(7):937-42. doi: 10.1002/eji.1830170707.
4
Capacity of sensitized thymus-derived lymphocytes to induce fatal lymphocytic choriomeningitis is restricted by the H-2 gene complex.致敏的胸腺来源淋巴细胞诱发致命性淋巴细胞性脉络丛脑膜炎的能力受H-2基因复合体的限制。
J Immunol. 1975 Jan;114(1 Pt 1):30-3.
5
Cell-mediated immunity in lumphocytic choriomeningitis. I. The specificity of the cytotoxic T lymphocytes.淋巴细胞性脉络丛脑膜炎中的细胞介导免疫。I. 细胞毒性T淋巴细胞的特异性。
Z Immunitatsforsch Exp Klin Immunol. 1976 Apr;151(3):224-36.
6
Mechanism of recovery from acute virus infection. VIII. Treatment of lymphocytic choriomeningitis virus-infected mice with anti-interferon-gamma monoclonal antibody blocks generation of virus-specific cytotoxic T lymphocytes and virus elimination.急性病毒感染的恢复机制。VIII. 用抗γ干扰素单克隆抗体治疗淋巴细胞性脉络丛脑膜炎病毒感染的小鼠可阻断病毒特异性细胞毒性T淋巴细胞的产生及病毒清除。
Eur J Immunol. 1989 Jul;19(7):1283-8. doi: 10.1002/eji.1830190720.
7
Murine hepatitis caused by lymphocytic choriomeningitis virus. II. Cells involved in pathogenesis.淋巴细胞性脉络丛脑膜炎病毒引起的小鼠肝炎。II. 发病机制中涉及的细胞。
Lab Invest. 1995 May;72(5):559-70.
8
Diminished T cell surveillance function in old mice infected with lymphocyte choriomeningitis virus.感染淋巴细胞性脉络丛脑膜炎病毒的老年小鼠中T细胞监视功能减弱。
Immunology. 1977 May;32(5):751-4.
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Persistent LCM virus infection in the mouse. Immunity and tolerance.小鼠持续性淋巴细胞脉络丛脑膜炎病毒感染。免疫与耐受。
Bull World Health Organ. 1975;52(4-6):471-8.
10
Immunosuppression by lymphocytic choriomeningitis virus infection: competent effector T and B cells but impaired antigen presentation.淋巴细胞性脉络丛脑膜炎病毒感染所致免疫抑制：效应T细胞和B细胞功能正常，但抗原呈递受损。
Eur J Immunol. 1992 Jul;22(7):1803-12. doi: 10.1002/eji.1830220720.

引用本文的文献

1
Lymphocytic choriomeningitis virus killer T cells are lethal only in weakly disseminated murine infections.淋巴细胞性脉络丛脑膜炎病毒杀伤性T细胞仅在轻度播散的小鼠感染中具有致死性。
J Exp Med. 1982 Jul 1;156(1):79-89. doi: 10.1084/jem.156.1.79.
2
Cytotoxic T cells are induced in mice infected with lymphocytic choriomeningitis virus strains of markedly different pathogenicities.在感染致病性明显不同的淋巴细胞性脉络丛脑膜炎病毒株的小鼠中可诱导出细胞毒性T细胞。
Infect Immun. 1982 May;36(2):598-602. doi: 10.1128/iai.36.2.598-602.1982.
3
Generation of autologous mixed leucocyte reactions during the course of infection with Theileria parva (East Coast Fever) in cattle.牛感染小泰勒虫（东海岸热）过程中自体混合淋巴细胞反应的产生
Immunology. 1980 Jun;40(2):229-37.
4
Production or prevention of neurologic disease by continuous lines of arenavirus-specific cytotoxic T lymphocytes.通过连续的沙粒病毒特异性细胞毒性T淋巴细胞系产生或预防神经疾病。
Med Microbiol Immunol. 1986;175(2-3):197-9. doi: 10.1007/BF02122450.
5
Directions for future research on the pathogenesis of arenaviral infections.沙粒病毒感染发病机制的未来研究方向。
Bull World Health Organ. 1975;52(4-6):753-60.

本文引用的文献

1
THE EPIDEMIOLOGY OF LYMPHOCYTIC CHORIOMENINGITIS IN WHITE MICE.淋巴细胞性脉络丛脑膜炎在小白鼠中的流行病学。
J Exp Med. 1936 Jul 31;64(2):183-200. doi: 10.1084/jem.64.2.183.
2
PERSISTENCE OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS IN IMMUNE ANIMALS AND ITS RELATION TO IMMUNITY.淋巴细胞性脉络丛脑膜炎病毒在免疫动物体内的持续存在及其与免疫的关系。
J Exp Med. 1936 May 31;63(6):847-61. doi: 10.1084/jem.63.6.847.
3
AN EPIDEMIC IN A MOUSE COLONY DUE TO THE VIRUS OF ACUTE LYMPHOCYTIC CHORIOMENINGITIS.由于急性淋巴细胞性脉络丛脑膜炎病毒而导致的鼠群爆发疫情。
J Exp Med. 1936 Mar 31;63(4):533-46. doi: 10.1084/jem.63.4.533.
4
PROTECTIVE EFFECT OF NEONATAL THYMECTOMY ON MOUSE LCM INFECTION.新生期胸腺切除对小鼠淋巴细胞脉络丛脑膜炎病毒感染的保护作用
Proc Soc Exp Biol Med. 1963 Oct;114:248-51. doi: 10.3181/00379727-114-28643.
5
Immune complex disease in chronic viral infections.慢性病毒感染中的免疫复合物疾病
J Exp Med. 1971 Sep 1;134(3 Pt 2):32s-40s.
6
Virus, cell surface, and self: lymphocytic choriomeningitis of mice.病毒、细胞表面与自身：小鼠淋巴细胞性脉络丛脑膜炎
Am J Clin Pathol. 1971 Sep;56(3):333-49. doi: 10.1093/ajcp/56.3.333.
7
Lymphocytic choriomeningitis virus: pathogenesis of acute central nervous system disease.淋巴细胞性脉络丛脑膜炎病毒：急性中枢神经系统疾病的发病机制
Fed Proc. 1971 Nov-Dec;30(6):1831-41.
8
Immunopathogenesis of acute central nervous system disease produced by lymphocytic choriomeningitis virus. II. Adoptive immunization of virus carriers.淋巴细胞性脉络丛脑膜炎病毒所致急性中枢神经系统疾病的免疫发病机制。II. 病毒携带者的过继免疫
J Exp Med. 1972 Apr 1;135(4):874-89. doi: 10.1084/jem.135.4.874.
9
Lymphocytic choriomeningitis. Pathogenesis.淋巴细胞性脉络丛脑膜炎。发病机制。
Prog Med Virol. 1974;18(0):94-110.
10
Pathogenesis of cerebellar hypoplasia produced by lymphocytic choriomeningitis virus infection of neonatal rats. 1. Evolution of disease following infection at 4 days of age.新生大鼠淋巴细胞性脉络丛脑膜炎病毒感染所致小脑发育不全的发病机制。1. 4日龄感染后的疾病演变。
J Neuropathol Exp Neurol. 1973 Jan;32(1):110-24. doi: 10.1097/00005072-197301000-00007.