Cole G A, Johnson E D
Bull World Health Organ. 1975;52(4-6):465-70.
Both recovery and death of mice following acute infections with lymphocytic choriomeningitis virus appear to be mediated by a population of virus-specific thymus-derived (T) effector lymphocytes that possess lytic activity in vitro against virus-infected syngeneic fibroblasts. Whether recovery or death occurs is determined by the balance between two interdependent factors: (1) the extent of virus-induced modifications in the surfaces of cells comprising "target" tissues, and (2) the efficiency of the immune inductive process leading to the generation of effector T lymphocytes that recognize and destroy these modified cells.
小鼠感染淋巴细胞性脉络丛脑膜炎病毒后,恢复或死亡似乎都由一群病毒特异性胸腺来源(T)效应淋巴细胞介导,这些细胞在体外对病毒感染的同基因成纤维细胞具有裂解活性。恢复或死亡的发生取决于两个相互依存因素之间的平衡:(1)病毒诱导的构成“靶”组织的细胞表面修饰程度,以及(2)导致产生识别并破坏这些修饰细胞的效应T淋巴细胞的免疫诱导过程的效率。