对体内和体外淋巴细胞脉络丛脑膜炎病毒感染的免疫反应。免疫介导疾病的机制。
Immune responses to LCM virus infection in vivo and in vitro. Mechanisms of immune-mediated disease.
作者信息
Cole G A, Johnson E D
出版信息
Bull World Health Organ. 1975;52(4-6):465-70.
Abstract
Both recovery and death of mice following acute infections with lymphocytic choriomeningitis virus appear to be mediated by a population of virus-specific thymus-derived (T) effector lymphocytes that possess lytic activity in vitro against virus-infected syngeneic fibroblasts. Whether recovery or death occurs is determined by the balance between two interdependent factors: (1) the extent of virus-induced modifications in the surfaces of cells comprising "target" tissues, and (2) the efficiency of the immune inductive process leading to the generation of effector T lymphocytes that recognize and destroy these modified cells.
摘要
小鼠感染淋巴细胞性脉络丛脑膜炎病毒后，恢复或死亡似乎都由一群病毒特异性胸腺来源（T）效应淋巴细胞介导，这些细胞在体外对病毒感染的同基因成纤维细胞具有裂解活性。恢复或死亡的发生取决于两个相互依存因素之间的平衡：（1）病毒诱导的构成“靶”组织的细胞表面修饰程度，以及（2）导致产生识别并破坏这些修饰细胞的效应T淋巴细胞的免疫诱导过程的效率。
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Immune responses to LCM virus infection in vivo and in vitro. Mechanisms of immune-mediated disease.对体内和体外淋巴细胞脉络丛脑膜炎病毒感染的免疫反应。免疫介导疾病的机制。
Bull World Health Organ. 1975;52(4-6):465-70.
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J Exp Med. 1982 Jul 1;156(1):79-89. doi: 10.1084/jem.156.1.79.
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Cytotoxic T cells are induced in mice infected with lymphocytic choriomeningitis virus strains of markedly different pathogenicities.在感染致病性明显不同的淋巴细胞性脉络丛脑膜炎病毒株的小鼠中可诱导出细胞毒性T细胞。
Infect Immun. 1982 May;36(2):598-602. doi: 10.1128/iai.36.2.598-602.1982.
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Production or prevention of neurologic disease by continuous lines of arenavirus-specific cytotoxic T lymphocytes.通过连续的沙粒病毒特异性细胞毒性T淋巴细胞系产生或预防神经疾病。
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Directions for future research on the pathogenesis of arenaviral infections.沙粒病毒感染发病机制的未来研究方向。
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本文引用的文献
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THE EPIDEMIOLOGY OF LYMPHOCYTIC CHORIOMENINGITIS IN WHITE MICE.淋巴细胞性脉络丛脑膜炎在小白鼠中的流行病学。
J Exp Med. 1936 Jul 31;64(2):183-200. doi: 10.1084/jem.64.2.183.
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PERSISTENCE OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS IN IMMUNE ANIMALS AND ITS RELATION TO IMMUNITY.淋巴细胞性脉络丛脑膜炎病毒在免疫动物体内的持续存在及其与免疫的关系。
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AN EPIDEMIC IN A MOUSE COLONY DUE TO THE VIRUS OF ACUTE LYMPHOCYTIC CHORIOMENINGITIS.由于急性淋巴细胞性脉络丛脑膜炎病毒而导致的鼠群爆发疫情。
J Exp Med. 1936 Mar 31;63(4):533-46. doi: 10.1084/jem.63.4.533.
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PROTECTIVE EFFECT OF NEONATAL THYMECTOMY ON MOUSE LCM INFECTION.新生期胸腺切除对小鼠淋巴细胞脉络丛脑膜炎病毒感染的保护作用
Proc Soc Exp Biol Med. 1963 Oct;114:248-51. doi: 10.3181/00379727-114-28643.
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Immune complex disease in chronic viral infections.慢性病毒感染中的免疫复合物疾病
J Exp Med. 1971 Sep 1;134(3 Pt 2):32s-40s.
6
Virus, cell surface, and self: lymphocytic choriomeningitis of mice.病毒、细胞表面与自身：小鼠淋巴细胞性脉络丛脑膜炎
Am J Clin Pathol. 1971 Sep;56(3):333-49. doi: 10.1093/ajcp/56.3.333.
7
Lymphocytic choriomeningitis virus: pathogenesis of acute central nervous system disease.淋巴细胞性脉络丛脑膜炎病毒：急性中枢神经系统疾病的发病机制
Fed Proc. 1971 Nov-Dec;30(6):1831-41.
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Immunopathogenesis of acute central nervous system disease produced by lymphocytic choriomeningitis virus. II. Adoptive immunization of virus carriers.淋巴细胞性脉络丛脑膜炎病毒所致急性中枢神经系统疾病的免疫发病机制。II. 病毒携带者的过继免疫
J Exp Med. 1972 Apr 1;135(4):874-89. doi: 10.1084/jem.135.4.874.
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