Pu S, Anisman H, Merali Z
School of Psychology, University of Ottawa, Ontario, Canada.
Neuroreport. 2000 Jun 5;11(8):1699-702. doi: 10.1097/00001756-200006050-00021.
Interleukin-1 (IL-1) administered either i.p. or i.c.v. provokes sickness behaviors, including suppression of feeding. As well, the possibility exists that IL-1 contributes to the cascade of factors that regulate feeding under basal conditions. The current study assessed the contribution of IL-1 in the control of food intake and body weight under physiological conditions in male rats. Pretreatment with an IL- I receptor antagonist (IL-1ra, 16 mg/kg, i.p.) completely blocked the suppression of food intake produced by injection of IL-1beta (4 microg/kg, i.p.). However, neither daily injections of IL-1ra (16 mg/kg, i.p.) for 4 consecutive days nor infusion of IL-1ra (500 microg/day, i.c.v.) for 7 days altered daily food intake and the rate of body weight gain. These findings suggest while IL-1 may play a role in anorexia associated with sickness, this cytokine likely does not play a physiological role in the regulation of daily food intake and long-term energy balance.
腹腔注射或脑室内注射白细胞介素-1（IL-1）会引发疾病行为，包括进食抑制。此外，IL-1有可能参与基础条件下调节进食的一系列因素。当前研究评估了IL-1在雄性大鼠生理条件下对食物摄入和体重控制中的作用。用IL-1受体拮抗剂（IL-1ra，16毫克/千克，腹腔注射）预处理可完全阻断注射IL-1β（4微克/千克，腹腔注射）所产生的食物摄入抑制。然而，连续4天每天注射IL-1ra（16毫克/千克，腹腔注射）或7天输注IL-1ra（500微克/天，脑室内注射）均未改变每日食物摄入量和体重增加速率。这些发现表明，虽然IL-1可能在与疾病相关的厌食症中起作用，但这种细胞因子可能在日常食物摄入调节和长期能量平衡中不发挥生理作用。
