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In vivo splicing and functional characterization of Mycobacterium leprae RecA.

作者信息

Frischkorn K, Springer B, Böttger E C, Davis E O, Colston M J, Sander P

机构信息

Medizinische Hochschule Hannover, Institut für Medizinische Mikrobiologie, 30625 Hannover, Germany.

出版信息

J Bacteriol. 2000 Jun;182(12):3590-2. doi: 10.1128/JB.182.12.3590-3592.2000.

Abstract

The RecA proteins from Mycobacterium tuberculosis and Mycobacterium leprae contain inteins. In contrast to the M. tuberculosis RecA, the M. leprae RecA is not spliced in Escherichia coli. We demonstrate here that M. leprae RecA is functionally spliced in Mycobacterium smegmatis and produces resistance toward DNA-damaging agents and homologous recombination.

摘要

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