Awasthy K S, Chaurasia O P, Sinha S P, Khan P K
Department of Zoology, Bhagalpur University, India.
Biomed Environ Sci. 2000 Mar;13(1):12-8.
The genotoxic potentiality of the crude leaf extract of Casearia tomentosa, a medicinal preparation, has been evaluated in Swiss albino mice. The extract significantly induced the division-disruptive chromosomal changes in bone marrow cells as well as in primary spermatocytes; the latter also exhibited marked increase in synaptic disruptions. A significant decrease in sperm count was noted. The incidence of structural damages in chromosomes, however, remained within the range of control level frequency. This herbal preparation, therefore, appears to be primarily spindle-poisoning in its action, but not clastogenic. The probable mechanism of this differential genotoxicity is discussed.
对药用植物绒毛嘉赐树的粗叶提取物的遗传毒性潜力在瑞士白化小鼠中进行了评估。该提取物显著诱导骨髓细胞以及初级精母细胞中分裂干扰性染色体变化；后者在突触破坏方面也表现出显著增加。精子数量显著减少。然而，染色体结构损伤的发生率仍在对照水平频率范围内。因此，这种草药制剂的作用似乎主要是纺锤体中毒，而非致断裂作用。讨论了这种差异遗传毒性的可能机制。
