Awasthy K S
Department of Zoology, K.K.M. College, Pakur, India.
Cytobios. 2001;106 Suppl 2:151-64.
The oral administration of a soxhlated crude ethanolic extract of leaves of neem (Azadirachta indica Ajuss; family Meliaceae) to adult male mice for 6 weeks (one spermatogenic duration) at the rate of 0.5, 1.0 or 2.0 g/kg body weight per day increased the incidences of structural changes and synaptic-disturbances in meiotic chromosomes and also caused more disruptions of meiosis. The extract reduced the sperm count and increased the frequency of spermatozoa with abnormal head morphology. It is suggested that at least one of the constituents of the extract may have interfered with the DNA. The result was chromosome strand breakages, or spindle disturbances, and the regulation of genes responsible for sperm shaping was affected.
将印楝（印楝属；楝科）叶的索氏提取粗乙醇提取物以每天0.5、1.0或2.0克/千克体重的剂量口服给予成年雄性小鼠6周（一个生精周期），增加了减数分裂染色体结构变化和突触紊乱的发生率，还导致减数分裂出现更多破坏。该提取物降低了精子数量，并增加了头部形态异常的精子频率。提示提取物中至少有一种成分可能干扰了DNA。结果导致染色体链断裂或纺锤体紊乱，影响了负责精子塑形的基因调控。
