大剂量甲氨蝶呤后用叶酸解救。I. 清除模式研究。
Methotrexate megadosage followed by folate rescue. I. A study in clearance patterns.
作者信息
Salasoo S, Irving M G, Lam-Po0Tang R, O'Gorman-Hughes D, Freedman A
出版信息
Med J Aust. 1976 May 22;1(21):777-9.
PMID:1085404
Abstract
Plasma clearance rates of methotrexate (MTX) have been determined in five patients given an infusion of 3,000 mg of MTX over six hours, followed by folate rescue 24 hours after the commencement of infusion. Results presented indicate that maintenance of high MTX concentrations and potential toxicity could not be related to age, body weight or surface area.
摘要
已对5名患者进行了甲氨蝶呤（MTX）的血浆清除率测定。这些患者在6小时内输注3000毫克MTX，然后在输注开始24小时后进行叶酸救援。给出的结果表明，MTX高浓度的维持和潜在毒性与年龄、体重或体表面积无关。
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