单卵双胞胎中的眼部格雷夫斯病。

Ophthalmic Graves' disease in monozygotic twins.

作者信息

Thornham F R, Nutt J E, Clark F

出版信息

Postgrad Med J. 1976 May;52(607):285-7. doi: 10.1136/pgmj.52.607.285.

DOI:10.1136/pgmj.52.607.285

PMID:1085447

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2496513/

Abstract

A pair of identical female twins with ophthalmic Graves' disease is described. Monozygosity was confirmed by analysis of blood groups and red cell isoenzymes. Thyroid status was assessed by standard tests (serum thyroxine (Thyopac-4), protein-bound iodine, Thyopac-3 and thyroid uptake of I). In addition, serum triiodothyronine and the response in thyroid stimulating hormone to thyrotrophin releasing hormone was measured. Circulating autoantibodies to thyroid tissue were detected in both sisters by complement fixation and immunofluorescence methods but long acting thyroid stimulator was not found.

摘要

本文描述了一对患有眼型格雷夫斯病的同卵双胞胎女性。通过血型和红细胞同工酶分析证实为单合子。通过标准检测（血清甲状腺素（Thyopac - 4）、蛋白结合碘、Thyopac - 3和碘的甲状腺摄取量）评估甲状腺状态。此外，还测量了血清三碘甲状腺原氨酸以及促甲状腺激素对促甲状腺激素释放激素的反应。通过补体结合和免疫荧光法在两姐妹中均检测到了针对甲状腺组织的循环自身抗体，但未发现长效甲状腺刺激素。