Kagan W A, Ascensão J A, Pahwa R N, Hansen J A, Goldstein G, Valera E B, Incefy G S, Moore M A, Good R A
Proc Natl Acad Sci U S A. 1976 Aug;73(8):2890-4. doi: 10.1073/pnas.73.8.2890.
Bone marrow from a patient with aplastic anemia was shown by multiple criteria to have a block in early myeloid differentiation. This block was overcome in vitro by elimination of marrow lymphocytes. Furthermore, this differentiation block was transferred in vitro to normal marrow by coculturing with the patient's marrow. We suggest that some cases of aplastic anemia may be due to an immunologically based suppression of marrow cell differentiation rather than to a defect in stem cells or their necessary inductive environment.
通过多种标准显示，再生障碍性贫血患者的骨髓在早期髓系分化中存在阻滞。通过消除骨髓淋巴细胞，这种阻滞在体外得以克服。此外，通过与患者骨髓共培养，这种分化阻滞在体外转移到了正常骨髓。我们认为，某些再生障碍性贫血病例可能是由于基于免疫的骨髓细胞分化抑制，而非干细胞或其必要诱导环境的缺陷所致。
