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血细胞减少在先，肝炎在后：再生障碍性贫血的一种不寻常顺序。

Cytopenia first - hepatitis second: an unusual sequence in aplastic anemia.

作者信息

Alashkar Ferras, Föhring Daniel, Dührsen Ulrich, Baba Hideo Andreas, Röth Alexander

机构信息

Department of Hematology West German Cancer Centre University Hospital Essen University of Duisburg-Essen Essen Germany.

Institute of Pathology University Hospital Essen University of Duisburg-Essen Essen Germany.

出版信息

Clin Case Rep. 2017 Apr 11;5(6):778-781. doi: 10.1002/ccr3.917. eCollection 2017 Jun.

DOI:10.1002/ccr3.917
PMID:28588809
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5458037/
Abstract

To the best of our knowledge, this is the first report of aplastic anemia (AA) preceding autoantibody-negative autoimmune hepatitis (AIH) with successful treatment of both conditions with the same immunosuppressive regimen, resulting in hematopoietic reconstitution and remission of AIH.

摘要

据我们所知，这是第一例再生障碍性贫血（AA）先于自身抗体阴性自身免疫性肝炎（AIH）的报告，且通过相同的免疫抑制方案成功治疗了这两种疾病，实现了造血重建和AIH缓解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e189/5458037/b88cf93d12c8/CCR3-5-778-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e189/5458037/68303dc62ad9/CCR3-5-778-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e189/5458037/b88cf93d12c8/CCR3-5-778-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e189/5458037/68303dc62ad9/CCR3-5-778-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e189/5458037/b88cf93d12c8/CCR3-5-778-g002.jpg

相似文献

1
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Clin Case Rep. 2017 Apr 11;5(6):778-781. doi: 10.1002/ccr3.917. eCollection 2017 Jun.
2
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3
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本文引用的文献

1
Expansion of a liver-infiltrating cytotoxic T-lymphocyte clone in concert with the development of hepatitis-associated aplastic anaemia.与肝炎相关性再生障碍性贫血发展相关的肝脏浸润性细胞毒性T淋巴细胞克隆的扩增。
Br J Haematol. 2013 May;161(4):599-602. doi: 10.1111/bjh.12259. Epub 2013 Feb 19.
2
Autoantibody-negative autoimmune hepatitis.自身抗体阴性自身免疫性肝炎。
Dig Dis Sci. 2012 Mar;57(3):610-24. doi: 10.1007/s10620-011-2017-z. Epub 2011 Dec 21.
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Hepatitis associated aplastic anemia: a review.肝炎相关性再生障碍性贫血：综述。
Virol J. 2011 Feb 28;8:87. doi: 10.1186/1743-422X-8-87.
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Diagnosis and management of autoimmune hepatitis.自身免疫性肝炎的诊断与管理
Hepatology. 2010 Jun;51(6):2193-213. doi: 10.1002/hep.23584.
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T-bet, a Th1 transcription factor, is up-regulated in T cells from patients with aplastic anemia.T-bet，一种Th1转录因子，在再生障碍性贫血患者的T细胞中表达上调。
Blood. 2006 May 15;107(10):3983-91. doi: 10.1182/blood-2005-10-4201. Epub 2006 Jan 24.
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Efficacy of tacrolimus in the treatment of steroid refractory autoimmune hepatitis.他克莫司治疗激素抵抗型自身免疫性肝炎的疗效
J Clin Gastroenterol. 2004 Oct;38(9):805-9. doi: 10.1097/01.mcg.0000139050.67178.be.
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Cyclosporine therapy in patients with steroid resistant autoimmune hepatitis.
Am J Gastroenterol. 1999 Jan;94(1):241-8. doi: 10.1111/j.1572-0241.1999.00807.x.
8
Aplastic anemia: presence in human bone marrow of cells that suppress myelopoiesis.再生障碍性贫血：人体骨髓中存在抑制骨髓生成的细胞。
Proc Natl Acad Sci U S A. 1976 Aug;73(8):2890-4. doi: 10.1073/pnas.73.8.2890.