Tanaka K, Ootsuyama A, Tanooka H, Ansell J D
Radiobiology Division, National Cancer Center Research Institute, Chuo-ku, Tokyo 104-0045, Japan.
Oncol Rep. 2000 Jul-Aug;7(4):897-8. doi: 10.3892/or.7.4.897.
A test system for examining the fused cell-origin of tumors was developed by application of Mus caroli carrying the X-chromosome inactivation cellular mosaicism for G6PD. A G6PD heterodimer pattern is expected if a tumor is initiated from a fused cell. Among tumors induced by subcutaneous injection of a high dose of MCA, three tumors exhibited a single G6PD phenotype and one tumor exhibited a multiple G6PD phenotype; however, the G6PD heterodimer pattern was not found. Although the results obtained were not conclusive, this system is thought to be useful for detecting a possible fused cell-origin of tumors.
通过应用携带G6PD X染色体失活细胞镶嵌现象的小鼠（Mus caroli），开发了一种用于检测肿瘤融合细胞起源的测试系统。如果肿瘤起源于融合细胞，则预期会出现G6PD异二聚体模式。在皮下注射高剂量MCA诱导的肿瘤中，三个肿瘤表现出单一的G6PD表型，一个肿瘤表现出多种G6PD表型；然而，未发现G6PD异二聚体模式。尽管所获得的结果尚无定论，但该系统被认为可用于检测肿瘤可能的融合细胞起源。
