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细胞镶嵌性小鼠中3-甲基胆蒽诱导的纤维肉瘤单细胞起源的证据。

Evidence for single-cell origin of 3-methylcholanthrene-induced fibrosarcomas in mice with cellular mosaicism.

作者信息

Tanooka H, Tanaka K

出版信息

Cancer Res. 1982 May;42(5):1856-8.

PMID:7066900
Abstract

Fibrosarcomas produced by s.c. injection of 5 micrograms of 3-methylcholanthrene in Pgk-1a/Pgk-1b mice carrying X-chromosome inactivation mosaicism for the phosphoglycerate kinase (PGK-1) gene contained only one type of phosphoglycerate kinase in seven of eight cases (88%), as judged from its electrophoretic mobility, indicating the single-cell origin of the tumor.

摘要

通过在携带磷酸甘油酸激酶（PGK-1）基因X染色体失活嵌合体的Pgk-1a/Pgk-1b小鼠中皮下注射5微克3-甲基胆蒽产生的纤维肉瘤，在八分之七的病例（88%）中，根据其电泳迁移率判断，仅含有一种类型的磷酸甘油酸激酶，表明肿瘤起源于单细胞。

相似文献

1
Evidence for single-cell origin of 3-methylcholanthrene-induced fibrosarcomas in mice with cellular mosaicism.细胞镶嵌性小鼠中3-甲基胆蒽诱导的纤维肉瘤单细胞起源的证据。
Cancer Res. 1982 May;42(5):1856-8.
2
Dose response of monoclonal tumor induction with 3-methylcholanthrene in mosaic mice.3-甲基胆蒽诱导嵌合体小鼠单克隆肿瘤的剂量反应
Cancer Res. 1984 Oct;44(10):4630-2.
3
Evidence concerning the clonal nature of chemically induced tumors: phosphoglycerate kinase-1 isozyme patterns in chemically induced fibrosarcomas.关于化学诱导肿瘤的克隆性质的证据：化学诱导纤维肉瘤中的磷酸甘油酸激酶-1同工酶模式。
J Natl Cancer Inst. 1985 Jan;74(1):145-50.
4
Probable clonal development of foreign-body-induced murine sarcomas.异物诱导的小鼠肉瘤可能的克隆性发展。
J Natl Cancer Inst. 1984 Feb;72(2):467-70.
5
Multicellular origin of fibrosarcomas in mice induced by the chemical carcinogen 3-methylcholanthrene.化学致癌物3-甲基胆蒽诱导的小鼠纤维肉瘤的多细胞起源
J Exp Med. 1979 Oct 1;150(4):878-87. doi: 10.1084/jem.150.4.878.
6
Clonal nature of mink cell focus-inducing virus-induced AKR leukemia: studies with X-chromosome inactivation cellular mosaicism.
J Natl Cancer Inst. 1983 Mar;70(3):529-33.
7
Clonal origin of tumors induced by ultraviolet radiation.紫外线辐射诱导肿瘤的克隆起源。
J Natl Cancer Inst. 1986 Jan;76(1):151-8.
8
Effect of solvents on methylcholanthrene-induced carcinogenesis in mice.溶剂对甲基胆蒽诱发小鼠致癌作用的影响。
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10
Xenotropic virus expression and susceptibility to 3-methylcholanthrene-induced cancer.嗜异性病毒表达与对3-甲基胆蒽诱导癌症的易感性
Cancer Res. 1980 Dec;40(12):4364-7.

引用本文的文献

1
Enhanced tumorigenicity of cloned UV-regressor tumor lines following selected in vivo and in vitro manipulations.经过特定的体内和体外操作后，克隆的紫外线消退肿瘤细胞系的致瘤性增强。
Am J Pathol. 1983 Dec;113(3):269-78.
2
Tumor heterogeneity: biological implications and therapeutic consequences.肿瘤异质性：生物学意义与治疗后果
Cancer Metastasis Rev. 1983;2(1):5-23. doi: 10.1007/BF00046903.
3
The selective nature of metastasis.转移的选择性本质。
Cancer Metastasis Rev. 1983;2(1):25-40. doi: 10.1007/BF00046904.
4
Intratumor immunologic heterogeneity.肿瘤内免疫异质性。
Cancer Metastasis Rev. 1982;1(4):319-34. doi: 10.1007/BF00124215.
5
Clonal origin of mouse liver cell tumors.小鼠肝细胞肿瘤的克隆起源。
Am J Pathol. 1985 Dec;121(3):426-32.
6
Macroscopic intestinal colonies of mice as a tool for studying differentiation of multipotential intestinal stem cells.将小鼠的宏观肠道菌落作为研究多能肠道干细胞分化的工具。
Am J Pathol. 1988 Jul;132(1):49-58.
7
Monoclonal growth of cancer cells: experimental evidence.癌细胞的单克隆生长：实验证据。
Jpn J Cancer Res. 1988 Jun;79(6):657-65. doi: 10.1111/j.1349-7006.1988.tb02217.x.
8
Clonal origin of skin and bone tumors produced by repeated beta-irradiation in mosaic cell mice.嵌合细胞小鼠经反复β射线照射后产生的皮肤和骨肿瘤的克隆起源。
Jpn J Cancer Res. 1992 Sep;83(9):964-7. doi: 10.1111/j.1349-7006.1992.tb02008.x.