Hershlag A, Zinger M, Lesser M, Scholl G, Bjornson L
North Shore University Hospital, New York University School of Medicine, Manhasset, New York, USA.
Fertil Steril. 2000 Jun;73(6):1174-8. doi: 10.1016/s0015-0282(00)00514-8.
To determine the correlation between serum estradiol measurements by chemiluminescent immunoassay (CIA) vs. radioimmunoassay (RIA) in two groups: patients treated with gonadotropins and patients treated with oral estrogen.
Prospective study.
Assisted Reproductive Technology (ART) program based in a university-affiliated hospital in Manhasset, New York.
PATIENT(S): Three hundred forty-eight patients undergoing gonadotropin stimulation and 63 patients receiving oral estrogen between July and December, 1997.
INTERVENTION(S): Estradiol levels were measured concomitantly on all patients undergoing gonadotropin stimulation for IVF and all patients receiving oral estrogen for a frozen-thaw cycle.
MAIN OUTCOME MEASURE(S): RIA:CIA ratio.
RESULT(S): In the group undergoing gonadotropin stimulation, the median RIA:CIA ratio was 0.92, RIA = 1.26 x CIA(0.96), r = 0.98. In the group receiving oral estrogen, the median ratio was 3.93, RIA = 2.9 x CIA(1.05), r = 0.89.
CONCLUSION(S): Estradiol levels determined by CIA correlate closely with RIA results for patients being treated with gonadotropins. Conversely, for patients receiving oral estrogen, CIA levels are one-third or less of the RIA level.
确定在两组患者中，通过化学发光免疫分析法（CIA）与放射免疫分析法（RIA）测定血清雌二醇之间的相关性。这两组患者分别为接受促性腺激素治疗的患者和接受口服雌激素治疗的患者。
前瞻性研究。
位于纽约曼哈塞特一家大学附属医院的辅助生殖技术（ART）项目。
1997年7月至12月期间，348例接受促性腺激素刺激的患者以及63例接受口服雌激素治疗的患者。
对所有接受体外受精促性腺激素刺激的患者以及所有接受冻融周期口服雌激素治疗的患者同时测定雌二醇水平。
RIA:CIA比值。
在接受促性腺激素刺激的组中，RIA:CIA比值中位数为0.92，RIA = 1.26×CIA(0.96)，r = 0.98。在接受口服雌激素的组中，比值中位数为3.93，RIA = 2.9×CIA(1.05)，r = 0.89。
对于接受促性腺激素治疗的患者，通过CIA测定的雌二醇水平与RIA结果密切相关。相反，对于接受口服雌激素治疗的患者，CIA水平为RIA水平的三分之一或更低。
