Krammer P H, Elliott B E, von Boehmer H
Eur J Immunol. 1976 Feb;6(2):138-9. doi: 10.1002/eji.1830060214.
A fraction of T cells activated to H-2 determinants in vivo (ATO) express Fc receptors (FcR) on the cell surface. Those FcR can be detected by antibody coated red blood cells (EA rosettes). Nonrosetting and EA rosetting ATC could be obtained in highly enriched form (more than 99% pure) by separation by velocity sedimentation at unit gravity. Separately tested, both fractions of ATC showed killer cell activity against specific target cells. Possible explanations why only one population of T killer cells expressed FcR are discussed.
在体内被激活以识别H-2决定簇的一部分T细胞（ATO）在细胞表面表达Fc受体（FcR）。那些FcR可用抗体包被的红细胞（EA玫瑰花结）检测到。通过单位重力下的速度沉降分离，可以以高度富集的形式（纯度超过99%）获得非玫瑰花结形成和EA玫瑰花结形成的ATO。分别测试时，ATO的两个部分均显示出针对特定靶细胞的杀伤细胞活性。文中讨论了为何只有一群T杀伤细胞表达FcR的可能解释。
