Kotĕsovec F, Skorkovský J, Brynda J, Peters A, Heinrich J
Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic.
Cent Eur J Public Health. 2000 May;8(2):120-7.
The association between short term changes in ambient air concentrations of TSP and SO2 and day to day fluctuations in mortality was analyzed in the highly polluted Northern Bohemia region inhabited by approximately 630,000 people. A logistic regression model was adjusted for long term trends, seasonal cycles, influenza epidemics and weather parameters. The pollution and mortality data were available from 1982 to 1994. When the association was evaluated regardless of gender and age, 100 micrograms/m3 increase of TSP, but not SO2, was associated with a 3.4% increase of daily mortality lagged by 2 days. Evident differences in this association have been found between men and women. A significant increase in daily total and CVD mortality was observed in men below 65 while in women of the same age we found no association or even significant decrease in daily mortality. For the population over 65 the differences between genders were again apparent. The mortality in women increased significantly while in men significant decrease was demonstrated.
The evaluation with respect to gender might contribute to identifying susceptible subgroups.
在约有63万人口居住的污染严重的北波希米亚地区，分析了总悬浮颗粒物（TSP）和二氧化硫（SO₂）的环境空气浓度短期变化与每日死亡率波动之间的关联。对长期趋势、季节周期、流感流行和天气参数进行了逻辑回归模型调整。污染和死亡率数据可追溯至1982年至1994年。当不考虑性别和年龄评估这种关联时，TSP每增加100微克/立方米（而非SO₂）与滞后2天的每日死亡率增加3.4%相关。在男性和女性之间发现了这种关联的明显差异。65岁以下男性的每日总死亡率和心血管疾病（CVD）死亡率显著增加，而在同一年龄段的女性中，我们未发现关联，甚至每日死亡率显著下降。对于65岁以上人群，性别差异再次显现。女性死亡率显著增加，而男性死亡率显著下降。
按性别进行评估可能有助于识别易感亚组。
