Soltysiak-Pawluczuk D, Bitny-Szlachto S
Int J Radiat Biol Relat Stud Phys Chem Med. 1976 Jun;29(6):549-53. doi: 10.1080/09553007614550651.
In mice X-irradiated with doses of 200 R and 400 R, there was a substantial increase in spleen adenyl cyclase activity; there was similar activation by MEA. In mice given MEA before irradiation, an additive effect of radiation and the radioprotective drug was observed. On the other hand, a dose of 800 R given either alone or after pre-treatment with MEA failed to elicit any change in cyclase activity. The results indicate the importance of the adenyl cyclase system in the response of cells to irradiation and action of MEA.
用200伦琴和400伦琴剂量进行X射线照射的小鼠，其脾脏腺苷酸环化酶活性显著增加；MEA也能产生类似的激活作用。在照射前给予MEA的小鼠中，观察到辐射和辐射防护药物的相加效应。另一方面，单独给予800伦琴剂量或在MEA预处理后给予该剂量，均未能引起环化酶活性的任何变化。结果表明腺苷酸环化酶系统在细胞对辐射的反应及MEA的作用中的重要性。
