Forsberg J, Harms-Ringdahl M, Ehrenberg L
Int J Radiat Biol Relat Stud Phys Chem Med. 1978 Sep;34(3):245-52. doi: 10.1080/09553007814550831.
The injection of ascrobate together with cysteamine (beta-mercaptoethylamin or MEA) was shown to cause a partial reversion of the radioprotective action of MEA in mice, and simultaneously of the suppressive action of MEA on RNA synthesis in bone marrow cells. In mouse spleen lymphocytes stimulated by concanavalin A in vitro, MEA and ascorbate exhibited a strong antagonism, neutralizing each other's inhibitory action on RNA synthesis. The latter effect failed to appear after chelation of trace metals, and it is indicated that the ability of ascorbate to counteract the effects of MEA on radiosensitivity and metabolism requires the formation of oxidized products, probably monodehydroascorbate, in agreement with previous observations on bacteria.
已表明，将抗坏血酸盐与半胱胺（β-巯基乙胺或MEA）一起注射会导致MEA对小鼠的辐射防护作用以及MEA对骨髓细胞RNA合成的抑制作用出现部分逆转。在体外由伴刀豆球蛋白A刺激的小鼠脾淋巴细胞中，MEA和抗坏血酸盐表现出强烈的拮抗作用，相互抵消对方对RNA合成的抑制作用。在微量金属螯合后，后一种效应未出现，这表明抗坏血酸盐抵消MEA对放射敏感性和代谢影响的能力需要形成氧化产物，可能是单脱氢抗坏血酸盐，这与先前对细菌的观察结果一致。
