Barrs V R, Martin P, Nicoll R G, Beatty J A, Malik R
Department of Veterinary Clinical Sciences, Faculty of Veterinary Science, University of Sydney, New South Wales.
Aust Vet J. 2000 Mar;78(3):154-8. doi: 10.1111/j.1751-0813.2000.tb10581.x.
A 12-year-old, FIV-positive, domestic longhair cat was presented with a history of sneezing and coughing during the previous seven months. On thoracic radiographs, a prominent bronchial pattern and three focal, opacified nodules were seen. Cytology of bronchoalveolar lavage fluid demonstrated spherical, capsulate, narrow-necked, budding yeasts within macrophages. Culture of the fluid yielded a heavy growth of Cryptococcus neoformans var neoformans. The serum latex cryptococcal antigen agglutination test titre was 158. The cat was treated with itraconazole and the cough resolved over a 5-month period but then recurred. Repeat thoracic radiographs showed resolution of the pulmonary nodules but a persistent bronchial pattern. Adult nematodes and ova with morphology characteristic of Capillaria aerophila were seen in bronchoalveolar lavage fluid and no yeasts were cultured from the fluid. The cryptococcal titre was zero. The lungworm infection was treated successfully with abamectin and the cough resolved. Immunosuppression related to FIV infection may have predisposed this cat to sequential respiratory tract infections.
一只12岁的FIV阳性家养长毛猫，在过去七个月中有打喷嚏和咳嗽的病史。胸部X光片显示有明显的支气管影像以及三个局灶性、不透明的结节。支气管肺泡灌洗液体细胞检查显示巨噬细胞内有球形、有荚膜、窄颈、出芽的酵母。液体培养产生了大量新型隐球菌变种新型隐球菌。血清乳胶隐球菌抗原凝集试验滴度为158。这只猫接受了伊曲康唑治疗，咳嗽在5个月内缓解，但随后又复发。重复胸部X光片显示肺部结节消失，但支气管影像持续存在。在支气管肺泡灌洗液体中发现了具有嗜气毛细线虫形态特征的成虫和虫卵，且液体培养未培养出酵母。隐球菌滴度为零。使用阿维菌素成功治疗了肺线虫感染，咳嗽也消失了。与FIV感染相关的免疫抑制可能使这只猫易患继发性呼吸道感染。
