Kłósek A, Hirnle L, Zimmer M, Tomiałowicz M, Zmijewski J, Fuchs T, Woytoń J, Kratz E, Siut J
Katedry i Kliniki Rozrodczości i Połoznictwa AM we Wrocławiu.
Ginekol Pol. 2000 Apr;71(4):298-303.
During uterus contractions detaching of amino-chorionic layer from uterus wall occurs and released fibronectin penetrates into amniotic fluid. The aim of this study was to estimate in a quantity mode the presence of fibronectin in amniotic fluid and to find the dependence between the fibronectin level in amniotic fluid and the period of time from collecting the sample to the labor. We wanted also to find the dependence between fibronectin level in amniotic fluid and duration of pregnancy, preterm rupture of amniotic membranes, patients' age, parity and number of deliveries. We analysed 86 pregnant women where we estimated the fibronectin level in specimens of amniotic fluid. During carrying out the experiment we noted that fibronectin is present in amniotic fluid and can be identified in a quantity mode. We have proved dependence between fibronectin level in amniotic fluid and the period of time from collecting the sample, up to the delivery. Fibronectin level in amniotic fluid in pregnancies uncomplicated with premature delivery was on the average 350 mg/ml. Increase of fibronectin in amniotic fluid above 700 mg/ml points at detaching of amino-chorionic layer and the occurrence of unavoidable preterm labor at the time no longer than 24 hours. Fibronectin level in amniotic fluid doesn't depend of pregnancy duration, preterm rupture of amniotic membranes.
在子宫收缩期间，氨基绒毛膜层会从子宫壁分离，释放出的纤连蛋白会渗透到羊水中。本研究的目的是以定量方式评估羊水中纤连蛋白的存在情况，并找出羊水中纤连蛋白水平与从采集样本到分娩的时间段之间的相关性。我们还想找出羊水中纤连蛋白水平与妊娠持续时间、胎膜早破、患者年龄、产次和分娩次数之间的相关性。我们分析了86名孕妇，评估了她们羊水样本中的纤连蛋白水平。在进行实验过程中，我们注意到纤连蛋白存在于羊水中，并且可以进行定量识别。我们已经证明了羊水中纤连蛋白水平与从采集样本到分娩的时间段之间存在相关性。无早产并发症的妊娠中，羊水中纤连蛋白水平平均为350毫克/毫升。羊水中纤连蛋白水平超过700毫克/毫升表明氨基绒毛膜层分离，且不可避免的早产将在不超过24小时内发生。羊水中纤连蛋白水平与妊娠持续时间、胎膜早破无关。
