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The structure of the complex formed by bovine trypsin and bovine pancreatic trypsin inhibitor III. Structure of the anhydro-trypsin-inhibitor complex.

作者信息

Huber R, Bode W, Kukla D, Kohl U, Ryan C A

出版信息

Biophys Struct Mech. 1975 May 30;1(3):189-201. doi: 10.1007/BF00535756.

DOI:10.1007/BF00535756
PMID:1086102
Abstract

The structure of the complex between anhydro-trypsin and pancreatic trypsin inhibitor has been determined by difference Fourier techniques using phases obtained from the native complex (Huber et al., 1974). It was refined independently by constrained crystallographic refinement at 1.9 A resolution. The anhydro-complex has Ser 195 converted to dehydro-alanine. There were no other significant structural changes. In particular, the high degree of pyramidalization of the C atom of Lys 15 (I) of the inhibitor component observed in the native complex in maintained in the anhydro-species.

摘要

相似文献

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The structure of the complex formed by bovine trypsin and bovine pancreatic trypsin inhibitor III. Structure of the anhydro-trypsin-inhibitor complex.
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2
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Electrostatic complementarity within the substrate-binding pocket of trypsin.胰蛋白酶底物结合口袋内的静电互补性。

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Structure of the complex formed by bovine trypsin and bovine pancreatic trypsin inhibitor. Crystal structure determination and stereochemistry of the contact region.牛胰蛋白酶与牛胰蛋白酶抑制剂形成的复合物结构。接触区域的晶体结构测定及立体化学
J Mol Biol. 1973 Jul 5;77(3):417-36. doi: 10.1016/0022-2836(73)90448-8.
7
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The association of anhydrotrypsin with the pancreatic trypsin inhibitors.
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The mechanism of the aminolysis of acetate esters.乙酸酯氨解的机理。
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