Zhao L, Li H, Han D
Department of Infectious Diseases, First Hospital of Shanxi Medical University, Taiyuan 030001, China.
Zhonghua Gan Zang Bing Za Zhi. 2001 Jul;9 Suppl:21-3.
To explore the effect of endotoxin on the development of cirrhosis.
The cirrhosis model with intestinal endotoxemia was made by oral intake of 0.03% thioacetamide for four months to observe the effect of endotoxin on the hepatic collagen contents in both thioacetamide and thioacetamide + lipopolysaccharide groups and to detect the contents of tumor necrosis factor-alpha (TNF-alpha), endothelin-1 (ET-1), nitric oxide (NO), and malondialdehyde (MDA) in the plasma and the hepatic homogenate.
The contents of TNF-alpha, ET-1, NO, and MDA in the plasma and the hepatic homogenate and the content of collagen in the hepatic tissue in the two groups were higher than those in the normal control group.
Endotoxin can accelerate liver fibrosis and the formation of cirrhosis.
探讨内毒素对肝硬化发展的影响。
通过口服0.03%硫代乙酰胺四个月建立伴有肠源性内毒素血症的肝硬化模型，观察内毒素对硫代乙酰胺组及硫代乙酰胺+脂多糖组肝组织胶原含量的影响，并检测血浆及肝匀浆中肿瘤坏死因子-α（TNF-α）、内皮素-1（ET-1）、一氧化氮（NO）和丙二醛（MDA）的含量。
两组血浆及肝匀浆中TNF-α、ET-1、NO和MDA的含量以及肝组织中胶原含量均高于正常对照组。
内毒素可加速肝纤维化及肝硬化的形成。
